Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
This study aimed to summarize the available data on the ethnomedicinal and phytopharmacological activities of L. based on database reports. For this purpose, an up-to-date literature search was carried out in the Google Scholar, Scopus, Springer Link, Web of Science, ScienceDirect, ResearchGate, PubMed, Chem Spider, Elsevier, BioMed Central, and patent offices (e.g., USPTO, CIPO, NPI, Google patents, and Espacenet) for the published materials. The findings suggest that the plant contains many important phytochemicals, including pyrrolizidine alkaloids, indicine, echinitine, supinine, heleurine, heliotrine, lasiocarpine, acetyl indicine, indicinine, indicine -oxide, cynoglossine, europine -oxide, heleurine -oxide, heliotridine -oxide, heliotrine -oxide, heliotrine, volatile oils, triterpenes, amines, and sterols. Scientific reports revealed that the herb showed antioxidant, analgesic, antimicrobial, anticancer, antituberculosis, antiplasmodial, anticataract, antifertility, wound healing, antiinflammatory, antinociceptive, antihyperglycemic, anthelmintic, diuretic, antitussive, antiglaucoma, antiallergic, and larvicidal activity. In conclusion, studies with animal models seem to show the potential beneficial effects of against a wide variety of disorders and as a source of phytotherapeutic compounds. However, clinical studies are necessary to confirm the effects observed in animal models, determine the toxicity of the therapeutic dose and isolate the truly bioactive components.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8187075 | PMC |
| http://dx.doi.org/10.1155/2021/9965481 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Absorption, distribution, and metabolism of pyrrolizidine alkaloids in tea plants: Insights from hydroponic exposure and molecular simulations.
Food Chem
August 2025
State Key Laboratory of Tea Plant Germplasm Innovation and Resource Utilization; Anhui Province Key Laboratory of Hazardous Factors and Risk Control of Agri-food Quality Safety, Anhui Agricultural University, Hefei 230036, China. Electronic address:
Pyrrolizidine alkaloids (PAs) secreted by weeds in tea gardens are absorbed by tea plants, but their distribution and metabolism remain unclear. Here, different types of PAs were soaked from Ageratum conyzoides L. and used in hydroponic experiments.
View Article and Find Full Text PDFPyrrolizidine alkaloid intoxication outbreaks in fattening pigs associated with drought-related feed contamination.
Porcine Health Manag
August 2025
Servei de Diagnòstic de Patologia Veterinària, Universitat Autònoma de Barcelona, Bellaterra, 08193, Spain.
Background: Pyrrolizidine alkaloid (PA) intoxication is a well-documented condition in livestock, resulting from the ingestion of forage and grain contaminated with PA-producing plants. These phytotoxins primarily affect the liver and can lead to severe clinical and pathological disorders, particularly in highly susceptibility species such as pigs. Although sporadic cases of chronic PA toxicosis have been reported in swine, extensive outbreaks affecting large geographic areas have not been previously documented.
View Article and Find Full Text PDFQSAR, molecular docking, MD simulations, and ADMET screening identify potential leads against key targets in benign prostatic hyperplasia.
In Silico Pharmacol
November 2024
Department of Biochemistry, Rivers State University, Port Harcourt, Rivers State Nigeria.
Unlabelled: Steroid 5α-reductase (5αR) converts testosterone into dihydrotestosterone (DHT), a potent androgen driving prostate cell proliferation via the androgen receptor (AR). Both 5αR and AR play crucial roles in androgen-mediated disorders, making them key therapeutic targets in drug development. Current treatments target these enzymes individually and often cause significant side effects, highlighting the need for safer alternatives.
View Article and Find Full Text PDFIndirect photodegradation of typical pyrrolizidine alkaloids in water induced by triplet states of dissolved organic matter.
J Hazard Mater
September 2024
State Key Laboratory of Pollution Control and Resources Reuse, College of Environmental Science and Engineering, Tongji University, Shanghai 200092, China; Shanghai Institute of Pollution Control and Ecological Security, Shanghai 200092, China.
The occurrence of pyrrolizidine alkaloids (PAs) in the aquatic environment has received growing attention due to their persistent mutagenicity and carcinogenicity. In this study, the photooxidation processes of four representative PAs (senecionine, senecionine N-oxide, europine, and heliotrine) in the presence of dissolved organic matter (DOM) were investigated. The excited triplet DOM (DOM*) was demonstrated to play a dominant role in the phototransformation of PAs.
View Article and Find Full Text PDFPyrrolizidine alkaloids and tropane alkaloids in milk samples from individual dairy farms of the German federal states of Bavaria and Schleswig-Holstein.
Food Addit Contam Part A Chem Anal Control Expo Risk Assess
June 2024
Chair of Food Safety and Analytics, Faculty of Veterinary Medicine, LMU in Munich, Munich, Germany.
1,2-Dehydro-pyrrolizidine alkaloids (PA), their corresponding -oxides (PANO) and tropane alkaloids (TA), are toxic plant metabolites. If plant material, containing these toxins, is present in the feed of dairy cows these toxins can be transferred into milk. Here, milk was sampled directly from dairy farms in the German federal states of Bavaria and Schleswig-Holstein in 2020-2022 in order to investigate a possible contamination of milk at the production stage.
View Article and Find Full Text PDF