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A requirement of the Construction Products Regulation (CPR) in the European Union states that construction works must be designed in such a way that throughout their entire life cycle, they have no exceedingly high environmental impact. The objective of the current work was to simulate the leaching of selected metals and sulfate in vertical test panels (VTPs) covered by plaster and mortar. The investigation is based on 18-month leaching outdoor tests (LOT) under real weather conditions. A leaching model was developed using the geochemical model PHREEQC with the Lawrence Livermore National Laboratory (LLNL) thermodynamic data base and coupled with MATLAB in order to optimize the run-off and weather parameters. The model was calibrated by comparing the data from laboratory Dynamic Surface Leaching Tests (DSLT) with simulation results up to an acceptable fit. The parameters obtained were then used in the LOT simulations and validated. The model allows predictions on the substance discharge from various plasters and mortars under real weather conditions. Physical characteristics of the material (e.g., thickness and absorption capacity) play an important role in the leaching of substances in façades covered with plaster and mortar. The lower the thickness and absorption capacity of the material applied, the greater the run-off and discharge of leached substances.
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http://dx.doi.org/10.1016/j.chemosphere.2021.130657 | DOI Listing |
EMBO Mol Med
September 2025
State Key Laboratory of Pathogen and Biosecurity, Academy of Military Medical Sciences, 100071, Beijing, China.
Traditional live attenuated vaccines (LAVs) are typically developed through serial passaging or genetic engineering to introduce specific mutations or deletions. While viral RNA secondary or tertiary structures have been well-documented for their multiple functions, including binding with specific host proteins, their potential for LAV design remains largely unexplored. Herein, using Zika virus (ZIKV) as a model, we demonstrate that targeted disruption of the primary sequence or tertiary structure of a specific viral RNA element responsible for Musashi-1 (MSI1) binding leads to a tissue-specific attenuation phenotype in multiple animal models.
View Article and Find Full Text PDFAerosp Med Hum Perform
September 2025
Introduction: This study investigated pilot cognitive engagement patterns across diverse flight conditions using electroencephalography (EEG)-based measurements in a high-fidelity rotary-wing simulation environment.
Methods: A total of 8 experienced U.S.
J Neurosci Methods
September 2025
Department of Biosciences and Bioinformatics, School of Science, Xi'an Jiaotong-Liverpool University, Suzhou, China; Suzhou Key Laboratory on Neurobiology and Cell Signaling, School of Science, Xi'an Jiaotong-Liverpool University, Suzhou, China.
Background: Affective disorders represent a major global health burden. Animal models are widely used for modeling brain disorders and neuroactive drug discovery. A novel powerful tool in translational neuroscience research, zebrafish provide multiple behavioral assays relevant to anxiety-like and depression-related conditions (including despair-like behavior, a common feature in depression).
View Article and Find Full Text PDFCortex
August 2025
Experimental Psychology and Methods, Universität Leipzig, Leipzig, Germany. Electronic address:
Effects of location- and object-based attention on sensory processing have been mostly studied in isolation leaving the relations between them less well understood. In an EEG experiment, temporal dynamics of location- and object-based attention were investigated with a probabilistic spatial cueing task to test temporal differences between sensory enhancement of two locations in one object. Stimuli consisted of two vertical rectangles/bars filled with a random noise pattern.
View Article and Find Full Text PDFJ Colloid Interface Sci
September 2025
College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology, Qingdao 266042, PR China. Electronic address:
Transition metal fluorides because of the high electronegativity of fluorine may enhance the local electron density of the metal sites and promote water molecule dissociation and charge transfer. However, enhancing the intrinsic activity of fluorides to improve material stability remains a challenge. Herein, we develop an innovative four-step synthetic strategy (electrochemical deposition → co-precipitation → ligand exchange → in situ fluorination) to engineer three-dimensional porous Fe-doped CoF nanocubes vertically anchored on MXene (Fe-CoF/MXene/NF).
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