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Barbara Gillespie Pickard (1936-2019) studied plant electrophysiology and mechanosensory biology for more than 50 y. Her first papers on the roles of auxin in plant tropisms were coauthored with Kenneth V. Thimann. Later, she studied plant electrophysiology. She made it clear that plant action potentials are not a peculiar feature of so-called sensitive plants, but that all plants exhibit these fast electric signals. Barbara Gillespie Pickard proposed a neuronal model for the spreading of electric signals induced by mechanical stimuli across plant tissues. In later years, she studied the stretch-activated plasma membrane channels of plants and formulated the plasma-membrane control center model. Barbara Pickard summarized all her findings in a new model of phyllotaxis involving waves of auxin fluxes and mechano-sensory signaling.
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http://dx.doi.org/10.1080/15592324.2021.1911400 | DOI Listing |
ACS Chem Neurosci
September 2025
Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, The College of Life Sciences, Northwest University, Xi'an 710069, P.R. China.
Developmental epileptic encephalopathies (DEEs), including Dravet syndrome (DS), require antiseizure medications (ASMs) that balance efficacy with developmental safety. There is an urgent clinical need for novel therapeutic agents that combine potent anticonvulsant activity with developmental safety. β-Asarone, an active constituent of plants, has demonstrated antiepileptic potential, but its toxicities severely limit clinical application.
View Article and Find Full Text PDFJACC Clin Electrophysiol
August 2025
Cardiology Hospital Haut Lévêque, Centre Hospitalier Universitaire (CHU), Bordeaux, Pessac, France; IHU LIRYC (Cardiac Electrophysiology and Modeling), University of Bordeaux, Bordeaux, France.
Neurotherapeutics
August 2025
Luzhou Key Laboratory of Activity Screening and Druggability Evaluation for Chinese Materia Medica, Key Laboratory of Medical Electrophysiology of Ministry of Education, Department of Cardiology, Department of Ophthalmology, The Affiliated Hospital of Southwest Medical University, School of Pharmacy
Alzheimer's disease (AD) pathology involves amyloid-beta (Aβ) accumulation and neuronal toxicity, highlighting the need for therapeutic strategies that can both inhibit Aβ aggregation and promote pathogenic protein clearance. In this study, we identified Gaultheria leucocarpa as a medicinal plant with promising neuroprotective potential. Thioflavin T (ThT) fluorescence screening revealed that extracts from G.
View Article and Find Full Text PDFSci Rep
August 2025
Department of Engineering, King Mongkut's Institute of Technology Ladkrabang, Prince of Chumphon Campus, Chumphon, Thailand.
ECa 233 is a standardized extract of Centella asiatica that contains the major active compounds madecassoside (MDS) and asiaticoside (ASS), which can strengthen hippocampal synapses, resulting in a memory-enhancing effect. This study explored the possible mechanisms of ECa 233 related to synaptic enhancement via proteomic analysis. Differentiated SH-SY5Y cells and hippocampal slices obtained from healthy male Wistar rats were treated with dimethyl sulfoxide, ECa 233, or the MDS + ASS mixture.
View Article and Find Full Text PDFInt J Med Sci
August 2025
Department of Longevity and Biofunctional Medicine, Pusan National University School of Korean Medicine, Yangsan 50612, Republic of Korea.
Koidzumi (AMK) is a traditional herbal medicine used for digestive disorders, yet its effects on colonic motility remain poorly understood. This study aimed to investigate the impact of AMK on human colonic contractility and pacemaker activity of interstitial cells of Cajal (ICCs), as well as its effect on intestinal transit. Human colonic tissues were obtained during non-obstructive colon surgery and used to assess spontaneous smooth muscle contractions and migrating motor complexes (MMCs).
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