Category Ranking

98%

Total Visits

921

Avg Visit Duration

2 minutes

Citations

20

Article Abstract

Unlabelled: The aim of the study was to determine the effect of simultaneous supplementation of β-hydroxy-β-methylbutyrate and L-Arginine α-ketoglutarate on lower limb power and muscle damage in medium distance runners aged 15.3 (±0.9) years old.

Methods: The study group consisted of 40 volunteers aged 14-17 years practicing medium distance running for at least two years. The study lasted 12 days and followed a randomized, double-blind, placebo-controlled, parallel design. All subjects attended a familiarization session on day 0 before the test. The subjects were randomly divided into two groups: supplements and placebo group. The same training cycle protocol was used in both groups during the 12-day training period. Morning warm-up involved 10 min jogging at 60-75% of maximal heart rate and countermovement jump height measurement. Main training units were carried out for both groups with the same volume. Training load assessment (the daily session Rating of Perceived Exertion (s-RPE) method) method takes into consideration the intensity and the duration of the training session to calculate the "training load" (TL).

Results: At the end of the training cycle, a significant ( = 0.002) decrease in the countermovement jump (CMJ) height was found in the placebo group when compared to the baseline. In the supplement group, there was no decrease in the countermovement jump height. Creatine kinase and lactate dehydrogenase concentration increased during the training days similarly in both groups and decreased on rest days. There were no differences between groups in enzymes concentration. The research results indicate that the supplement combination used in the supplements group prevented a reduction in the CMJ values. In contrast to the supplements group, in the placebo group, the CMJ changes were statistically significant: a noticeable ( = 0.002) decrease in CMJ was noted between the baseline measurement and the 6th measurement. The well-being of the subjects from both groups changed significantly during the training period, and the intergroup differences in the mood level were similar and not statistically significant.

Conclusions: The results of this study indicate that the daily co-supplementation with calcium salt of β-hydroxy-β-methylbutyrate (7.5 g) and L-Arginine α-ketoglutarate (10 g) during training might help to prevent decline in jump performance. No influence on muscle damage markers or mood was shown.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8064357PMC
http://dx.doi.org/10.3390/nu13041064DOI Listing

Publication Analysis

Top Keywords

β-hydroxy-β-methylbutyrate l-arginine
12
l-arginine α-ketoglutarate
12
placebo group
12
countermovement jump
12
training
9
jump performance
8
muscle damage
8
medium distance
8
training cycle
8
training period
8

Similar Publications

Essential tremor (ET) is a common neurological disease that is characterized by 4-12 Hz kinetic tremors of the upper limbs and high genetic heterogeneity. Although numerous candidate genes and loci have been reported, the etiology of ET remains unclear. A novel ET-related gene was initially identified in a five-generation family via whole-exome sequencing, and other variants were identified in 772 familial ET probands and 640 sporadic individuals via whole-genome sequencing.

View Article and Find Full Text PDF

Enhancer RNAs (eRNAs) are transcribed by during enhancer activation but are typically rapidly degraded in the nucleus. During states of reduced RNA surveillance, however, eRNAs and other similar "noncoding" RNAs (including, e.g.

View Article and Find Full Text PDF

NFATc3 and PML Synergistically Regulate Tumor-Associated Gene Expression in a SUMOylation-Independent Manner.

Biochimie

September 2025

Department of Oncology, Xin Hua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200092, China. Electronic address:

The nuclear factor of activated T cells 3 (NFATc3) plays a significant role in various cancer-related processes, but its interactions with transcriptional modulators, particularly Promyelocytic Leukemia protein (PML), remain poorly understood. PML, a nuclear scaffold protein, is involved in tumor suppression and transcriptional regulation. This study investigates the interaction between NFATc3 and PML, focusing on the role of SUMOylation and its impact on downstream target genes.

View Article and Find Full Text PDF

Ethnopharmacological Relevance: Chronic inflammatory pain represents a significant global health burden, seriously affecting the patient's quality of life. Jin-Tian-Ge Capsules (JTG), a substitute for natural tiger bone, has been approved in China for the treatment of osteoporosis, osteoarthritis and rheumatoid arthritis. Clinical observations show that JTG can mitigate chronic pain associated with the above bone-related diseases.

View Article and Find Full Text PDF

Screening for anti-dysmenorrhea components of Wenjing Decoction: spectral-effect relationship analysis, and efficacy equivalence validation.

J Ethnopharmacol

September 2025

The First Hospital of Hunan University of Chinese Medicine, Changsha 410007, China; Key Laboratory of Research and Transformation on Prevention and Treatment of Major Diseases in Internal Medicine of Traditional Chinese Medicine, Ministry of Education, Changsha 410007, China. Electronic address: mic

Ethnopharmacological Relevance: Primary dysmenorrhea (PD) is common and has a major impact on women's daily activities and quality of life. Wenjing Decoction (WD), a classic Chinese medicine formula, has been widely used for thousands of years in China to treat PD. However, the key pharmacodynamic substances in WD responsible for its anti-dysmenorrhea efficacy are still unclear.

View Article and Find Full Text PDF