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Article Abstract
Soluble epoxide hydrolase (sEH) is an enzyme that is considered a potential therapeutic target in human cardiovascular disease. Triterpenes (-) and phenylpropanoids (-) were isolated from to obtain sEH inhibitors through various chromatographic purificationtechniques. The isolated compounds were evaluated for their inhibitory activity against sEH, and methyl rosmarinate (), martynoside (), dimethyl lithospermate () and 9″ methyl lithospermate () showed remarkable inhibitory activity, with the IC values ranging from 10.6 ± 3.2 to 35.7 ± 2.1 µM. Kinetic analysis of these compounds revealed that , and were competitive inhibitors bound to the active site, and was the preferred mixed type inhibitor for allosteric sites. Additionally, molecular modeling has identified interacting catalytic residues and bindings between sEH and inhibitors. The results suggest that these compounds are potential candidates that can be used for further development in the prevention and treatment for cardiovascular risk.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7917821 | PMC |
| http://dx.doi.org/10.3390/plants10020356 | DOI Listing |
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