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http://dx.doi.org/10.1136/bmj.n541 | DOI Listing |
Front Psychol
August 2025
Faculty of Information Technology, Monash University, Melbourne, VIC, Australia.
Psychology's crises (e.g., replicability, generalisability) are currently believed to derive from Questionable Research Practices (QRPs), thus scientific misconduct.
View Article and Find Full Text PDFAngew Chem Int Ed Engl
September 2025
Department of Optical Nanoscopy, Max Planck Institute for Medical Research, Jahnstrasse 29, 69120, Heidelberg, Germany.
Controlled photoactivation is an auspicious and emerging approach in super-resolution microscopy, offering virtually zero background signal from the marker prior to activation. Pyronins are well-established fluorophores, but due to their inherent intercalating tendency towards nucleic acids, their use has been mostly avoided in super-resolution microscopy. Here, we describe a new class of diaryl ether and diaryl silane molecules that upon photoactivation close into fluorescent (silicon-)pyronins and term them Pyronin Upon Light Irradiation (PULI).
View Article and Find Full Text PDFBioinformatics
September 2025
School of Computer Science and Technology, Beijing Institute of Technology, Beijing, 100081, China.
Motivation: Therapeutic peptide is an important ingredient in the treatment of various diseases and drug discovery. The toxicity of peptides is one of the major challenges in peptide drug therapy. With the abundance of therapeutic peptides generated in the post-genomics era, it is a challenge to promptly identify toxicity peptides using computational methods.
View Article and Find Full Text PDFFood Sci Nutr
September 2025
Nutritional immunity is an essential defense process by which the host restricts the supply of critical micronutrients to invading pathogens, thus hindering their survival and growth. During wound infections, this mechanism is instrumental in determining the course of host-pathogen interactions. This article discusses the pathophysiology of wound infection, beginning with the classification of wounds as acute and chronic wounds, and emphasizes how compromised epithelial barriers and chronic inflammation provide a niche for microbial colonization.
View Article and Find Full Text PDFChem Sci
August 2025
University of Warwick, Department of Chemistry Library Road Coventry CV4 7AL UK
Photochemistry mediated by visible light is attractive as it avoids the limitations of higher energy UV light. Photo-induced copper-mediated reversible deactivation radical polymerisation (photo Cu-RDRP) typically requires both a copper catalyst and a separate photocatalyst (PC) to exploit lower energy irradiation. However, by covalently anchoring a PC to another reagent, dual functionality can be established.
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