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The positive effect of low-intensity pulsed ultrasound (LIPUS) on bone fracture healing has been proved. However, during the period of LIPUS therapy, it is undetermined whether LIPUS promotes the formation of heterotopic ossification (HO), which usually occurs in muscle tissues after trauma such as bone fracture and spinal cord injury. Here, we used 6-week LIPUS therapy in a 42-year-old Chinese male patient with a fracture nonunion in combination with ultrasonography for monitoring fracture healing and HO formation. After the LIPUS therapy, the mineralized bone formation in the area of defect of the distal tibia was presented in an ultrasound image, which was consistent with the outcome of plain radiography showing callus formation and the blurred fracture line in the area exposed to LIPUS. In addition, ultrasound images revealed no evidence of HO development within soft tissues during the period of LIPUS therapy. This study suggests that ultrasonography is a potential tool to guarantee the performance of LIPUS therapy with monitoring HO formation. Easy to use, the integration of the handheld ultrasound scanner and the ultrasonic therapeutic apparatus is entirely dedicated to help orthopedists make high-quality care and diagnosis.
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http://dx.doi.org/10.1155/2021/8834795 | DOI Listing |
BMC Musculoskelet Disord
September 2025
State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases, Sichuan University, Chengdu, China.
Background: Low-intensity pulsed ultrasound (LIPUS) is an effective therapy for craniofacial bone regeneration. Paracrine signaling from mesenchymal stem cells (MSCs) plays a critical role in bone repair, but the impact of LIPUS on MSC-derived secretome remains unclear. This study investigates whether LIPUS enhances the osteogenic and angiogenic potential of MSCs through modulation of growth factor secretion.
View Article and Find Full Text PDFNucleosides Nucleotides Nucleic Acids
September 2025
Center for Molecular Biophysics, CNRS Orleans, Orleans, France.
Heart failure (HF) is not a disease but a combination of signs and symptoms caused by the failure of the heart to pump blood to support the circulatory system at rest or during activity. HF is the potential end stage of all heart diseases in which cardiomyopathies are a diverse group of cardiac disorders with distinct phenotypes, depending on the protein and pathways affected. Cardiomyopathies represent major causes of morbidity and mortality at all ages in humans in which hypertrophic cardiomyopathy (HCM) and dilated cardiomyopathy (DCM), are the most common.
View Article and Find Full Text PDFBiochem Pharmacol
August 2025
The First Affiliated Hospital, Gynecology &Obstetrics and Reproductive Medical Center, Hengyang Medical School, University of South China, Hengyang, Hunan 421001, China
Polycystic Ovary Syndrome (PCOS) is a prevalent endocrine and metabolic condition among women of reproductive age, frequently associated with oxidative stress (OS) and chronic low-grade inflammation. Low-Intensity pulsed ultrasound (LIPUS) is a safe, non-invasive physical therapy method widely used in promoting fracture healing, soft tissue repair, and reducing inflammation. This study explored the improving effect of LIPUS on ovarian function in PCOS rat models induced by letrozole and a high-fat diet.
View Article and Find Full Text PDFSci Rep
August 2025
XingJiang Zhaosu County Xiyu Horse Industry Co., Ltd, Yili, 835600, Xinjiang, China.
The incidence of sports injuries in horses is increasing, thus accurate assessment, diagnosis, and treatment are critical. Among common sports-related injuries, proximal sesamoid bone fractures (PSBFs) are one of the most frequent types. To investigate the effects of low-intensity pulsed ultrasound (LIPUS) on imaging and hematological parameters of PSBFs, providing a clinical reference for the diagnosis and treatment of PSBFs in racehorses.
View Article and Find Full Text PDFJ Nanobiotechnology
August 2025
Sichuan Higher Education Institute Key Laboratory of Major Disease Target Discovery and Protein Drug Development, School of Bioscience and Technology, Chengdu Medical College, Chengdu, 610500, P. R. China.
Thrombotic diseases pose life-threatening risks, yet current thrombolytic therapies face limitations including poor targeting and bleeding risks. To address this, ultrasound-activatable nanomotors (hBT-Pt@Pm) were developed through the integration of hollow BaTiO₃/Pt Schottky heterojunctions with platelet membrane (Pm) coatings. The hollow structure enhances piezocatalytic efficiency by shortening charge migration distances, while Pt deposition improves carrier separation, collectively boosting reactive oxygen species (ROS) generation under ultrasound.
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