Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Human brain pathways supporting language and declarative memory are thought to have differentiated substantially during evolution. However, cross-species comparisons are missing on site-specific effective connectivity between regions important for cognition. We harnessed functional imaging to visualize the effects of direct electrical brain stimulation in macaque monkeys and human neurosurgery patients. We discovered comparable effective connectivity between caudal auditory cortex and both ventro-lateral prefrontal cortex (VLPFC, including area 44) and parahippocampal cortex in both species. Human-specific differences were clearest in the form of stronger hemispheric lateralization effects. In humans, electrical tractography revealed remarkably rapid evoked potentials in VLPFC following auditory cortex stimulation and speech sounds drove VLPFC, consistent with prior evidence in monkeys of direct auditory cortex projections to homologous vocalization-responsive regions. The results identify a common effective connectivity signature in human and nonhuman primates, which from auditory cortex appears equally direct to VLPFC and indirect to the hippocampus. VIDEO ABSTRACT.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7927917 | PMC |
| http://dx.doi.org/10.1016/j.neuron.2020.12.026 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Environmental Stresses Constrain Soil Microbial Community Functions by Regulating Deterministic Assembly and Niche Width.
Mol Ecol
September 2025
State Key Laboratory of Soil and Water Conservation and Desertification Control, College of Soil and Water Conservation Science and Engineering, Northwest A&F University, Shaanxi, People's Republic of China.
Increasing evidence indicates that the loss of soil microbial α-diversity triggered by environmental stress negatively impacts microbial functions; however, the effects of microbial α-diversity on community functions under environmental stress are poorly understood. Here, we investigated the changes in bacterial and fungal α- diversity along gradients of five natural stressors (temperature, precipitation, plant diversity, soil organic C and pH) across 45 grasslands in China and evaluated their connection with microbial functional traits. By quantifying the five environmental stresses into an integrated stress index, we found that the bacterial and fungal α-diversity declined under high environmental stress across three soil layers (0-20 cm, 20-40 cm and 40-60 cm).
View Article and Find Full Text PDFMean Airway Pressure-An Informative but Overlooked Indicator of Mechanical Power.
Crit Care Explor
September 2025
Division of Pulmonary, Allergy, Critical Care, and Sleep, University of Minnesota, Minneapolis, MN.
Mean airway pressure, a monitored variable continuously available on the modern ventilator, is the pressure measured at the airway opening averaged over the time needed to complete the entire respiratory cycle. Mean airway pressure is well recognized to connect three key physiologic processes in mechanical ventilation: physical stretch, cardiovascular dynamics, and pulmonary gas exchange. Although other parameters currently employed in adults to determine "safe" ventilation are undoubtedly valuable for daily practice, all have limitations for continuous monitoring of ventilation hazard.
View Article and Find Full Text PDFIndoor Air Quality Conditions and Respiratory Virus Detections in Elementary Schools-Kansas City, Missouri, February-March 2023.
Indoor Air
January 2025
National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Background/objectives: Respiratory viruses circulate year-round and can spread indoors via inhalation of airborne particles. Effective ventilation and filtration may reduce transmission, particularly in school settings where children and staff spend significant time. This study examines the impact of indoor air quality (IAQ) and ventilation in schools on respiratory virus detection.
View Article and Find Full Text PDFPhytochemical alkaloids orchestrate immunometabolism against viral infections.
Natl Sci Rev
September 2025
School of Life Science, Beijing University of Chinese Medicine, Beijing 100029, China.
The role of cholesterol metabolism in antiviral immunity has been established, but if and how this cholesterol-mediated immunometabolism can be regulated by specific small molecules is of particular interest in the quest for novel antiviral therapeutics. Here, we first demonstrate that NPC1 is the key cholesterol transporter for suppressing viral replication by changing cholesterol metabolism and triggering the innate immune response via systemic analyses of all possible cholesterol transporters. We then use the Connectivity Map (CMap), a systematic methodology for identifying functional connections between genetic perturbations and drug actions, to screen NPC1 inhibitors, and found that bis-benzylisoquinoline alkaloids (BBAs) exhibit high efficacy in the inhibition of viral infections.
View Article and Find Full Text PDFThe interaction of online co-creative performance in a paired-player mode with creative tendency as a moderator.
Front Psychol
August 2025
Program of Learning Sciences, National Taiwan Normal University, Taipei, Taiwan.
This study investigated the moderating effect of individuals' creative tendencies on their creative performance in interactive situations. A sample of 292 participants was selected to engage in various assessments, including the Alternative Uses Test (AUT) and the Chinese Radical Remote Associates Test (CRRAT) in single-player and paired-player modes. Additionally, participants completed the Creative Tendency Scale (CTS) as part of the data collection process.
View Article and Find Full Text PDF