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Based on the detailed three-dimensional (3D) finite element (FE) limit analyses, the present study investigates the plastic limit loads of complex-cracked pipes with two-layered materials for determining maximum load-carrying capacity or critical crack length of pipes with two-layered materials. The complex cracks in pipes with two-layered materials consist of a partial through-wall crack and 360-deg circumferential surface crack in the inner side of pipe in the same plane in pipe, which could be developed in the preemptive weld overlay region on the dissimilar metal weld (DMW) of nuclear pipe. In terms of FE limit analyses for complex-cracked pipes with two-layered materials, total thickness of pipe, depth of 360-deg internal surface crack, length of partial through-wall crack and the effect of strength mismatch between two materials are systematically considered in the present study. As for loading conditions, axial tension, global bending moment, and internal pressure are employed in the present FE analyses, and then, the confidence of the present FE procedure is confirmed by comparing the FE results with the existing solutions for complex cracks in single material. The results of the present FE plastic limit loads are compared with the existing solutions for complex-cracked pipes with two-layered materials. Also, a simple approach using equivalent single material based on the weighted average concept instead of using the properties of two materials is suggested for predicting plastic limit loads of two-layered materials. The present results can be applied to leak-before-break (LBB) analyses of nuclear piping with weld overlay.
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http://dx.doi.org/10.1115/1.4042444 | DOI Listing |
Int J Pharm
October 2025
Instituto de Ciencia de Materiales de Madrid (ICMM), CSIC, Madrid 28049, Spain.
Eumycetoma and other subcutaneous mycosis are severe chronic infections with a high incidence in tropical and subtropical regions, whose current treatment has a low curation rate. In the search for more effective and affordable therapies, hybrid materials based on amphotericin B (AmB), an antifungal drug with a broad spectrum of action, appear promising for localized treatment at the site of infection. In this context, the immobilization of AmB in suitable nanocarriers would be helpful to minimize its adverse side effects and ensure a controlled release over time.
View Article and Find Full Text PDFiScience
August 2025
Department of Biomedical Engineering, University of North Texas, Denton, TX, USA.
To meet the emerging demand for constraining engineered probiotic activities, many biocontainment studies explore strategies that involve killing engineered microbes, which often create basal levels of cytotoxicity that hamper cell fitness and performance. Here, we explored a circuit design that destroys the engineered genetic materials in a probiotic strain, instead of killing these cells, under non-permissive conditions. Our safeguard circuit involves a two-layered transcriptional regulatory circuit to control the expression of a CRISPR system that targets the engineered genes for degradation.
View Article and Find Full Text PDFSmall
July 2025
College of Materials Science and Engineering, Ocean University of China, Qingdao, 266100, China.
Energy-efficient thermal management is critical for addressing the inevitable heat generation and inefficient heat dissipation of conventional solar cells. Designing cooling systems that optimize optical windows, solar conversion, interfacial properties and aesthetic appeal for diverse photovoltaic technologies remains a significant challenge. Herein, passive cooling membranes are developed as "front surfaces" for both silicon-based (inorganic) and polymer (organic) solar cells.
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June 2025
Department of Electrical and Computer Engineering, University of Patras, 26504 Patras, Greece.
We consider light, high-absorbance, low-reflectance, electrically large layered sheet structures composed of thin carbon nanotube films. Such structures can be utilized in electromagnetic absorption and shielding applications in the X-band. They are of increasing interest in sensor-enabling technologies, stealth systems, and EMI shielding of electronic components.
View Article and Find Full Text PDFACS Appl Mater Interfaces
July 2025
School of Materials Science and Engineering, Georgia Institute of Technology, Atlanta, Georgia 30332, United States.
Capturing shearing stresses is crucial for accurately monitoring multidirectional mechanical deformation, enabling advanced motion analysis and enhancing functionality in wearable and robotic applications. Here, we present self-powered porous piezo-ionic shear-sensing materials that simultaneously resolve normal and tangential stresses with high sensitivity, a broad dynamic range, and high linearity. A composite of thermoplastic urethane and ionic liquids, reinforced with silica nanoparticles, was exploited to establish and sustain a porous framework.
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