Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Information processing in the brain is mediated by structural white matter pathways and is highly dependent on topological brain properties. Here we combined transcranial magnetic stimulation (TMS) with high-density electroencephalography (EEG) and Diffusion Weighted Imaging (DWI), specifically looking at macroscale connectivity to understand whether regional, network-level or whole-brain structural properties are more responsible for stimulus propagation. Neuronavigated TMS pulses were delivered over two individually defined nodes of the default mode (DMN) and dorsal attention (DAN) networks in a group of healthy subjects, with test-retest reliability assessed 1-month apart. TMS-evoked activity was predicted by the modularity and structural integrity of the stimulated network rather than the targeted region(s) or the whole-brain connectivity, suggesting network-level structural connectivity as more relevant than local and global brain properties in shaping TMS signal propagation. The importance of network structural connectome was unveiled only by evoked activity, but not resting-state data. Future clinicals interventions might enhance target engagement by adopting DWI-guided, network-focused TMS.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9094638 | PMC |
| http://dx.doi.org/10.1016/j.neuroimage.2020.117698 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Tension-sensitive LINC-RhoA signaling prevents chromatin bridge breakage in cytokinesis.
EMBO J
September 2025
Department of Biology, University of Crete, Vassilika Vouton, Heraklion, 70013, Greece.
In the presence of chromatin bridges in cytokinesis, human cells retain actin-rich structures (actin patches) at the base of the intercellular canal to prevent chromosome breakage. Here, we show that daughter nuclei connected by chromatin bridges are under mechanical tension that requires interaction of the nuclear membrane Sun1/2-Nesprin-2 Linker of Nucleoskeleton and Cytoskeleton (LINC) complex with the actin cytoskeleton, and an intact nuclear lamina. This nuclear tension promotes accumulation of Sun1/2-Nesprin-2 proteins at the base of chromatin bridges and local enrichment of the RhoA-activator PDZ RhoGEF through PDZ-binding to cytoplasmic Nesprin-2 spectrin repeats.
View Article and Find Full Text PDFQueer temporality in Tony Kushner's angels in America.
J Aging Stud
September 2025
University of Graz, Department of American Studies, Attemsgasse 25/II, 8010 Graz, Austria. Electronic address:
Tony Kushner's Angels in America, written in two parts during the early 1990s, vividly depicts the experiences of queer individuals confronting the AIDS crisis. Examined through the framework of anocriticism and queer temporality, the play challenges traditional life trajectories focused on reproduction, aging, and progress. Drawing on the work of theorists such as Roberta Maierhofer, Jack Halberstam, and Elizabeth Freeman, this analysis investigates how the play's fragmented narrative and interplay of supernatural and historical elements blur the boundaries between past, present, and future.
View Article and Find Full Text PDFNeuroimaging Biomarkers in Postpartum Depression: A Comprehensive Review of Structural, Functional, and Metabolic Alterations.
Behav Brain Res
September 2025
Key Laboratory of Endocrine Glucose & Lipids Metabolism and Brain Aging, Ministry of Education, Department of Radiology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jing-wu Road No. 324, Jinan 250021, Shandong, China. Electronic address:
Postpartum Depression (PPD) is a significant perinatal mood disorder affecting many new mothers in the first postpartum year. It is characterized by emotional, cognitive, and behavioral changes, often leading to delayed diagnosis due to nonspecific symptoms. PPD arises from a complex interplay of neuroendocrine, genetic, and psychosocial factors.
View Article and Find Full Text PDFSystematic Review of Experimental Studies in Humans on Transcranial Temporal Interference Stimulation.
J Neural Eng
September 2025
Eindhoven University of Technology, De Rondom 70, Eindhoven, 5612 AP, NETHERLANDS.
Transcranial temporal interference stimulation (tTIS) has recently emerged as a non-invasive neuromodulation method aimed at reaching deeper brain regions than conventional techniques. However, many questions about its effects remain, requiring further experimental studies. This review consolidates the experimental literature on tTIS's effects in the human brain, clarifies existing evidence, identifies knowledge gaps, and proposes future research directions to evaluate its potential.
View Article and Find Full Text PDFRelationships among humanistic literacy competencies in Chinese clinical nurses: A network analysis.
Nurse Educ Pract
September 2025
School of Medicine, Wuhan University of Science and Technology, Wuhan, Hubei 430065, China. Electronic address:
Aim: This study examined the network structure of the competency cluster of humanistic literacy among clinical nurses in China, identifying key and bridging competencies within the network cluster.
Background: With the increasing demand for high-quality healthcare services and the growing complexity of nurse-patient relationships, the humanistic competence of clinical nurses has received increasing attention. However, compared with the international level and professionalism, the humanistic literacy and education of nursing staff in Chinese medical institutions still has significant room for improvement.