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Background: Intensive Care Units (ICU) have sometimes been overwhelmed by the surge of COVID-19 patients. Extending ICU capacity can be limited by the lack of air and oxygen pressure sources available. Transport ventilators requiring only one O source may be used in such places.
Objective: To evaluate the performances of four transport ventilators and an ICU ventilator in simulated severe respiratory conditions.
Materials And Methods: Two pneumatic transport ventilators, (Oxylog 3000, Draeger; Osiris 3, Air Liquide Medical Systems), two turbine transport ventilators (Elisee 350, ResMed; Monnal T60, Air Liquide Medical Systems) and an ICU ventilator (Engström Carestation-GE Healthcare) were evaluated on a Michigan test lung. We tested each ventilator with different set volumes (Vt = 350, 450, 550 ml) and compliances (20 or 50 ml/cmHO) and a resistance of 15 cmHO/l/s based on values described in COVID-19 Acute Respiratory Distress Syndrome. Volume error (percentage of Vt) with P of 4 cmHO and trigger delay during assist-control ventilation simulating spontaneous breathing activity with P of 4 cmHO and 8 cmHO were measured.
Results: Grouping all conditions, the volume error was 2.9 ± 2.2% for Engström Carestation; 3.6 ± 3.9% for Osiris 3; 2.5 ± 2.1% for Oxylog 3000; 5.4 ± 2.7% for Monnal T60 and 8.8 ± 4.8% for Elisee 350. Grouping all conditions (P of 4 cmHO and 8 cmHO), trigger delay was 50 ± 11 ms, 71 ± 8 ms, 132 ± 22 ms, 60 ± 12 and 67 ± 6 ms for Engström Carestation, Osiris 3, Oxylog 3000, Monnal T60 and Elisee 350, respectively.
Conclusions: In surge situations such as COVID-19 pandemic, transport ventilators may be used to accurately control delivered volumes in locations, where only oxygen pressure supply is available. Performances regarding triggering function are acceptable for three out of the four transport ventilators tested.
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http://dx.doi.org/10.1186/s13613-020-00782-5 | DOI Listing |
ACS Nano
September 2025
State Key Laboratory of Materials-Oriented Chemical Engineering, National Engineering Research Center for Special Separation Membrane, Nanjing Tech University, Nanjing 210009, China.
Airborne pathogens and pollution control typically necessitate multiple membranes, each specializing in efficient aerosol filtration, moisture regulation, or antimicrobial protection. Integrating all these functions into a single membrane is highly advantageous but remains inherently challenging due to material incompatibility and inevitable performance trade-offs. Here, we present a photoactive Janus nanofibrous membrane for highly efficient air purification, engineered via sequential electrospinning.
View Article and Find Full Text PDFPlacenta
September 2025
Centre for Perinatal and Neonatal Medicine, Tohoku University Hospital, Sendai, Japan; Department of Obstetrics and Gynaecology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; School of Veterinary Medicine, Murdoch University, Perth, Western Australia, Australia; Women
Introduction: Antenatal steroid (ANS) therapy accelerates preterm lung maturation. Clinical and experimental data show current regimens disrupt placental function and transport and impact fetal growth. We have previously shown that higher materno-fetal steroid exposures increase fetal glucocorticoid clearance.
View Article and Find Full Text PDFNurs Crit Care
September 2025
Grantley Stable Neonatal Unit, Royal Brisbane and Women's Hospital, Herston, Queensland, Australia.
Background: Newborn infants represent a significant percentage of childhood deaths (>60%) with over 90% of newborn end-of-life care taking place in an acute hospital setting. This is in direct contrast to adults and children where specialised hospital or hospice care is used during their palliative care experience. To support family choice, a neonatal retrieval service developed a new model of care to transfer babies from a hospital to a hospice, a hospital closer to home or a private residence for palliative care while being cuddled by a parent.
View Article and Find Full Text PDFPLoS One
September 2025
Center of Emergency Medicine, University Hospital Essen, Essen, Germany.
Background: Survival of out-of-hospital cardiac arrest (OHCA) remains poor even when bystander cardiopulmonary resuscitation (CPR) with chest compression is initiated. Chest compressions provide only reduced cardiac output with limited perfusion of heart and brain and therfore may not avoid both death or poor neurological outcome in prolonged CPR. We investigated the impact of resuscitative endovascular balloon occlusion of the aorta (REBOA) on hemodynamics, gas exchange and return of spontanous circulation (ROSC) with short-term survival during mechanical CPR (mCPR) with chest compression synchronized-ventilation (CCSV) in an atraumatic pig model.
View Article and Find Full Text PDFPhysiol Rep
September 2025
Division of Pulmonary, Critical Care, Sleep, and Allergy Medicine, University of Arizona, Tucson, Arizona, USA.
Post-acute sequelae of SARS-CoV-2 (PASC or "long COVID") and chronic fatigue syndrome/myalgic encephalitis (CFS/ME) share symptoms such as exertional dyspnea. We used exercise oxygen pathway analysis, comprising six parameters of oxygen transport and utilization, to identify limiting mechanisms in both conditions. Invasive cardiopulmonary exercise testing was performed on 15 PASC patients, 11 CFS/ME patients, and 11 controls.
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