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http://dx.doi.org/10.2147/RMHP.S265942 | DOI Listing |
Eur J Med Res
September 2025
Department of Zoology, Faculty of Science, Ain Shams University, Abbassia, Cairo, 11566, Egypt.
Nuclear receptors (NRs) are a superfamily of ligand-activated transcription factors that regulate gene expression in response to metabolic, hormonal, and environmental signals. These receptors play a critical role in metabolic homeostasis, inflammation, immune function, and disease pathogenesis, positioning them as key therapeutic targets. This review explores the mechanistic roles of NRs such as PPARs, FXR, LXR, and thyroid hormone receptors (THRs) in regulating lipid and glucose metabolism, energy expenditure, cardiovascular health, and neurodegeneration.
View Article and Find Full Text PDFNat Aging
September 2025
Department of Clinical Molecular Biology, University of Oslo and Akershus University Hospital, Lørenskog, Norway.
Beyond their classical functions as redox cofactors, recent fundamental and clinical research has expanded our understanding of the diverse roles of nicotinamide adenine dinucleotide (NAD) and nicotinamide adenine dinucleotide phosphate (NADP) in signaling pathways, epigenetic regulation and energy homeostasis. Moreover, NAD and NADP influence numerous diseases as well as the processes of aging, and are emerging as targets for clinical intervention. Here, we summarize safety, bioavailability and efficacy data from NAD-related clinical trials, focusing on aging and neurodegenerative diseases.
View Article and Find Full Text PDFBioinspir Biomim
September 2025
Mechanical Intelligence (MI) Research Group, London South Bank University, 103 Borough Road, London, London, SE1 0AA, UNITED KINGDOM OF GREAT BRITAIN AND NORTHERN IRELAND.
Conventional rigid grippers remain the most-used robotic grippers in industrial assembly tasks. However, they are limited in their ability to handle a diverse range of objects. This study draws inspiration from nature to address these limitations, employing multidisciplinary methods, such as computer-aided design, parametric modeling, finite element analysis, 3D printing, and mechanical testing.
View Article and Find Full Text PDFInt J Food Microbiol
September 2025
College of Food Science, Henan Institute of Science and Technology, Xinxiang, Henan, 453003, China. Electronic address:
This study comprehensively evaluated the antimicrobial efficacy and mechanisms of ε-polylysine (ε-PL) against Yersinia enterocolitica (Y. enterocolitica) contamination in pre-prepared meat products. Surveillance data from retail pork and beef samples collected in Xi'an, China (May 2024 to April 2025) revealed a 50.
View Article and Find Full Text PDFEcotoxicol Environ Saf
September 2025
Key Laboratory of Karst Georesources and Environment (Guizhou University), Ministry of Education, College of Resources and Environmental Engineering, Guizhou University, Guiyang 550025, China.
Despite global phase-out initiatives, legacy polychlorinated biphenyls (PCBs) remobilize in marine ecosystems as secondary emission sources, posing ecotoxicological and human health risks emerge through cross-trophic dietary exposure pathways. This study aimed to systematically examined the distribution, trophic transfer properties, and health risks of PCBs in six fish and eight invertebrate species from the Beibu Gulf in southern China, by stable isotope analysis, hierarchical cluster analysis, and Monte Carlo simulation. The ΣPCBs concentrations ranged from 0.
View Article and Find Full Text PDF