The needs and unmet needs for people living with dementia, caregivers and care workers in dementia health care systems: a systematic review.

Introduction: The prevalence and costs of dementias are rising due to demographic changes. Dementia care depends largely on informal caregivers and fragmented healthcare systems that often fail to meet the needs of people with dementia.

Objectives: This systematic review aims to identify unmet needs and barriers in European dementia care, providing a framework to improve health strategies.

Five Neural Architecture Comparison to Evaluate Performance Algorithm and Calculate Length of Stay of Patient Undergoing Kidney Surgery.

In order to estimate patient length of stay (LOS) and determine the variables that affect, machine learning techniques use intricate datasets and algorithms. Support vector machines (SVMs), neural networks, decision trees, regression models, random forests, and so forth are among the most popular learning techniques. In this paper, for LOS prediction, neural networks process sequence and image data.

Predicting Length of Stay in Ophthalmology Patients: A Neural Network Approach.

Hospitalization duration after ophthalmic surgery varies widely, affecting costs, resource use, and outcomes. Length of stay (LOS) is key for hospital efficiency and patient management. Prolonged stays raise expenses and strain capacity, while early discharge risks complications.

Learning from COVID-19: A Systematic Review of the IHR-SPAR Framework's Role in the Pandemic Response.

The International Health Regulations (IHR) provide a global framework for health security, requiring annual reporting on 35 indicators across 15 core capacities via the State Parties Annual Reporting (SPAR) tool. The COVID-19 pandemic exposed gaps in the IHR framework and monitoring systems, prompting calls for reform. This systematic review analyzed the correlations between IHR-SPAR scores and pandemic outcomes across nine studies (2020-2024), selected using the PRISMA guidelines.

Fluoride Release from Pediatric Dental Restorative Materials: A Laboratory Investigation.

Dental caries remains a prevalent issue in pediatric dentistry, necessitating restorative materials that not only repair decay but also provide protective benefits. Fluoride-releasing restorative materials have a key function in preventing recurrent caries by inhibiting bacterial activity and promoting remineralization. The objective of this study was to examine fluoride release from three pediatric dental restorative materials-, , and the -under different pH and temperature conditions.

Using Statistical Learning to Investigate the Characteristics that Contribute to Extended Hospital Stays After Testicular Cancer Surgery.

Testicular cancer (TC) is a relatively rare but highly treatable malignancy that originates in the germ cells of the testicles. It primarily affects young men, particularly those between the ages of 15 and 35, though it can occur at any age. The most common histological subtypes are seminoma and non-seminomatous germ cell tumors (NSGCTs), the latter including embryonal carcinoma, yolk sac tumor, choriocarcinoma, and teratoma.

Modeling Hospital Stay for Patients with Kidney Cancer.

With its rapid course and dismal prognosis, kidney cancer poses serious oncology issues. The only therapy that may be curative is surgical resection, although this procedure has significant morbidity and necessitates meticulous postoperative care. After surgery, the duration of hospital stay (LOS) is a crucial indicator of clinical results and resource use.

Using Statistical Learning to Examine Variables that Contribute to Longer Hospital Stays After Endometrial Cancer Surgery.

Endometrial cancer, primarily arising from the lining of the uterus (endometrium), is the most common gynecological malignancy in many developed countries. Risk factors include obesity, age, and a family history of related cancers. The prognosis is generally favorable when detected early.

Sp4/HD11 and Sp1/HAT-p300 complexes induce apoptotic cell death in CuCl-treated neurons by modulating histone acetylation on BCL-W and BAX promoters.

Copper is a metal physiologically present in the brain that becomes neurotoxic at high concentrations; on the other hand, pharmacological inhibition of Histone Deacetylases (HDs) or of Histone Acetyltransferases (HATs) reduce neuronal death caused by several neurotoxicants. Herein, we found that CuCl (300 μM in SH-SY5Y cells or 100 μM in cortical neurons) determined apoptotic cell death, that was counteracted by the class IV HDs inhibitor Mocetinostat (MOCE) and by the HAT-p300 inhibitor C646, but not by the class I and II HDs inhibitors. Interestingly, HD11 and HAT-p300 protein levels increased after both 12 and 24 h of CuCl exposure and their silencing partially limited CuCl-neurodetrimental effect.

The structural and organizational aspects of human papillomavirus vaccine affecting immunization coverage in Europe: a systematic review.

The introduction of HPV vaccinations, that can prevent most prevalent HPV-related cancers of various body districts, is a public health milestone. Despite broad immunization programs, European Health Systems face structural and organizational difficulties that hinder care. This study examined structural and organizational elements that may affect HPV vaccine coverage.

The Effect of Different pH and Temperature Values on Ca, F, PO, OH, Si, and Sr Release from Different Bioactive Restorative Dental Materials: An In Vitro Study.

Bioactive restorative materials are crucial for promoting remineralization and protecting dental tissues through ion release. This study examines how pH and temperature influence the short- and long-term ion (F, Ca, Sr, OH, Si, and PO) release from seven commercial materials: , , , , , , and . Disks were prepared according to the manufacturers' instructions; immersed in buffer solutions at pH 4.

Barriers for access and utilization of dementia care services in Europe: a systematic review.

Background: Dementia is a group of chronic diseases characterised by cognitive impairment that progressively disrupts daily functioning and requires increasing levels of healthcare, social support, and long-term care. Support for people with dementia can be provided by formal support systems although most of the care process relies upon informal care givers. Despite the availability of formal support systems and healthcare workers, the utilization of dementia care services remains suboptimal.

Use of artificial intelligence to study the hospitalization of women undergoing caesarean section.

Objective: The incidence of caesarean sections (CSs) has increased significantly in recent years, especially in developed countries. This study aimed to identify the factors that most influence the length of hospital stay (LOS) after a CS, using data from 9,900 women who underwent CS at the "Federico II" University Hospital of Naples between 2014 and 2021.

Methods: Various artificial intelligence models were employed to analyze the relationships between the LOS and a set of independent variables, including maternal and foetal characteristics.

Inhibition of biofilm formation and preformed biofilm in by resveratrol, chlorhexidine and benzalkonium: modulation of efflux pump activity.

Introduction: The persistence of in the contaminated environment is sustained by tolerance to biocides and ability to growth as biofilm. The aim of the study was to analyze the susceptibility of biofilms to chlorhexidine (CHX) and benzalkonium (BZK) biocides and the ability of natural monomeric stilbenoid resveratrol (RV) to modulate the phenomenon.

Methods: Biofilm formation and preformed biofilm were tested by Crystal violet and tetrazolium salt reduction assay, respectively.

Behind the scenes: exploring neurological journal editors' work habits, decisions, and potential sources of conflict of interest.

Background And Objectives: Editors of scientific journals play a key role in the health-related research process. Our study aims to characterize the demographics, work habits, decision-making processes, and ethical challenges faced by editors of neurological journals and to evaluate associations between editor or journal characteristics and editorial decisions, as well as sources of conflict of interest.

Methods: Cross-sectional study involving editors from neurological journals that fell above the 50th percentile in the Scimago rankings.

Technological interventions in European dementia care: a systematic review of acceptance and attitudes among people living with dementia, caregivers, and healthcare workers.

Background: Alzheimer's and other neurodegenerative forms of dementia affect 8 million Europeans. Assistive technologies are suggested to reduce the burden of care and improve the quality of life of person living with dementia. Nonetheless, the acceptance and attitudes toward technological interventions pose challenges not only for people living with dementia and caregivers but also for healthcare workers.

Advancing Analytical Techniques in PET and rPET: Development of an ICP-MS Method for the Analysis of Trace Metals and Rare Earth Elements.

Despite the extensive use of recycled polyethylene terephthalate (rPET) in food contact materials (FCMs), research on the presence of heavy metals (HMs) and rare earth elements (REEs) during various recycling stages (e.g., flakes, granules, and preforms) remains limited.

Logistic and organizational barriers to herpes zoster vaccination in europe: A systematic review.

Background: The Herpes Zoster (HZ) poses a significant public health threat, leading to morbidity and occasional mortality in unvaccinated adults aged 50 and older. With over 95 % of individuals in this age group globally having prior exposure to Varicella-Zoster Virus, a substantial portion of the world's population is susceptible to developing HZ. Without vaccination, individuals reaching 85 years face a 50 % lifetime risk of HZ.

Pediatric-onset Multiple Sclerosis treatment: a multicentre observational study comparing natalizumab with fingolimod.

Background: Pediatric-onset Multiple Sclerosis (POMS) patients show more inflammatory disease compared with adult-onset MS. However, highly effective treatments are limited with only fingolimod being approved in Italy and natalizumab prescribed as off-label treatment.

Objectives: to compare the efficacy of natalizumab versus fingolimod in POMS.

Consumer awareness and knowledge regarding use of non-steroidal anti-inflammatory drugs (NSAIDs) in a metropolitan area.

Background: Non-steroidal anti-inflammatory drugs (NSAIDs) have well-known adverse effects, and numerous studies have shown inappropriate behaviors regarding their use. The primary aim of this study was to analyze the knowledge, attitudes, and behaviors regarding the use of NSAIDs simultaneously in one of the largest and most populated areas of Italy, Naples.

Methods: From 2021 December 14th to 2022 January 4th, a cross-sectional survey study was conducted among community centers, working places, and universities using a snowball sampling method.

Utilization of Ocrelizumab within Different Treatment Strategies for Multiple Sclerosis: A 5-Year Population-Based Study.

Background: We aim to provide up-to-date real-world evidence on the persistence, adherence, healthcare resource utilization, and costs of multiple sclerosis (MS) by comparing ocrelizumab to other disease-modifying treatments (DMTs) and within different DMT sequences.

Methods: We included 3371 people with MS who first received or switched DMT prescriptions from January 2018 to December 2022; they were identified through hospital discharge records, drug prescriptions, and exemption codes from the Campania Region (South Italy). We calculated persistence (time from the first prescription to discontinuation or switching to another DMT), adherence (proportion of days covered (PDC)), DMT costs, and MS hospital admissions and related costs.

An ecological analysis of socio-economic determinants associated with paediatric vaccination coverage in the Campania Region: A population-based study, years 2003-2017.

Introduction: Vaccines are the most cost-effective and straightforward intervention against severe infectious diseases. However, in Europe and in Italy, paediatric vaccination coverage for certain vaccines remains suboptimal, with considerable regional differences in Italy. Vaccine coverage varies significantly due to socio-economic and organisational factors.

Assessing Heavy Metals in the Sele River Estuary: An Overview of Pollution Indices in Southern Italy.

Rapid industrialization, coupled with a historical lack of understanding in toxicology, has led in an increase in estuary pollution, frequently resulting in unexpected environmental situations. Therefore, the occurrence of heavy metals (HMs) constitutes a major environmental issue, posing a serious risk both to aquatic ecosystems and public health. This study aimed to evaluate the levels of eight HMs (As, Hg, Cd, Cr, Cu, Ni, Pb, and Zn) in water, suspended particles, and sediment near the Sele River estuary (Italy) in order to assess their environmental impacts on the sea and health risks for humans.