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Background And Purpose: Proximal hamstring tendinopathy is a chronic, overuse condition that commonly develops in athletes. Eccentric exercise has been widely accepted in the clinic as the treatment of choice for the management of tendinopathies. However, this form of treatment has seldom been compared to other forms of load-based management for hamstring tendinopathies. Heavy slow resistance training, which consists of both concentric and eccentric phases, increases the loading time experienced by the tendon compared to eccentric only exercises. Heavy slow resistance training has achieved positive clinical results in the management of Achilles and patellar tendinopathy.
Purpose: The purpose of this case report is to describe the outcomes of a powerlifter with proximal hamstring tendinopathy who responded favorably to a heavy slow resistance biased rehabilitation program after traditional, conservative management failed to alleviate symptoms.
Case Description: A 31-year-old male competitive powerlifter was seen in physical therapy for the management of proximal hamstring tendinopathy. The subject had experienced long duration pain localized at the ischial tuberosity combined with hip weakness that limited his ability to lift weigtht and sit for longer than 30 minutes. Treatment included a 12-week heavy slow resistance program with the focus of increasing load intensity.
Outcomes: Numeric pain-rating scale was assessed at baseline, after a 12-week heavy slow resistance protocol, and 12 months post protocol. Within four weeks of starting the heavy slow resistance program, the subject noted a meaningful decrease in pain. The subject experienced clinically important improvements in numeric pain-rating scale immediately after the protocol and these improvements remained 12 months after completing the protocol. The subject was able to return to competitive powerlifting after the 12-week program.
Discussion: A meaningful change in pain occurred within four weeks of starting the program and continued improvement throughout the remainder of the 12 weeks with outcomes maintained 12 months after completing the program suggests that increasing the loading strategy with a heavy slow resistance program was helpful for this subject.
Level Of Evidence: 4.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7575155 | PMC |
http://dx.doi.org/10.26603/ijspt20200814 | DOI Listing |
Chemosphere
September 2025
Department of Materials Design and Innovation, University at Buffalo, NY, 14260, USA. Electronic address:
Bioremediation offers a sustainable strategy for mitigating heavy metal contamination in soil, but is often constrained by slow removal kinetics, limited uptake efficiency, and high implementation costs. This study investigates dried mycelium membranes, rich in surface-bound proteins and high surface area, as a promising biosorbent for in situ Pb(II) remediation in urban soils. Untreated mycelium membranes buried in soil achieved Pb(II) removal efficiencies of ∼70 % and ∼40 % at initial lead soil concentrations of 100 mg/kg and 1500 mg/kg, respectively, within eight days.
View Article and Find Full Text PDFChemistry
September 2025
State Key Laboratory of Heavy Oil Processing, China University of Petroleum (Beijing), Beijing, 102249, China.
This study introduces the HydroTherm-Flow Smart Window (HTF Window), the first groundbreaking integration of thermochromic windows and Fe-Cr redox flow batteries (Fe-Cr RFBs), achieving dual functionalities of dynamic solar modulation-via dual-band (visible + near-infrared, NIR) modulation-and high-efficiency energy storage in a single component. Leveraging tunable hydroxypropyl cellulose (HPC) hydrogels, it enables ultrafast optical switching and autonomous nighttime opacity, overcoming the slow response and privacy limitations of conventional thermochromic systems. By repurposing the window as a compact electrolyte reservoir, it reduces the RFB spatial footprint while enhancing ionic conductivity by 30% via hydrogel "ion highways," achieving 77% energy efficiency with a 40% reduction in the solar heat gain coefficient.
View Article and Find Full Text PDFThe exquisitely organized sarcomere, the unit of contraction of striated muscle, is a stable structure with slow turnover of its components. The myosin chaperone UNC-45 and its binding partners, Hsp90 and Hsp70, are required for the initial folding of the myosin head domain and the assembly of myosin into thick filaments. There is increasing evidence that the UNC-45 system has an important role during aging to preserve sarcomere organization.
View Article and Find Full Text PDFUnlabelled: As human skeletal muscle cellular and molecular contractile properties are temperature-sensitive, the ability to perform experiments at body temperature (∼37°C) may lead to a better understanding of their responses and potentially their effects upon whole-muscle and whole-body performance. We quantified molecular (myosin-actin cross-bridge mechanics and kinetics) and cellular (specific tension; force divided by cross-sectional area) function in slow-contracting myosin heavy chain (MHC) I and fast-contracting MHC IIA fibers from older adults (n=13, 8 female) at 37°C and compared these to results at 25°C. MHC I fibers were more temperature-sensitive than MHC IIA fibers, showing greater increases in cross-bridge kinetics (MHC I: 4.
View Article and Find Full Text PDFJ Am Chem Soc
August 2025
State Key Laboratory of Heavy Oil Processing, College of Chemical Engineering and Environment, China University of Petroleum (Beijing), Beijing 102249, China.
Electrochemical reduction of CO to formate over Sn-based catalysts offers an effective carbon-neutral approach for chemical production and renewable energy storage. However, poor selectivity under high current densities persists, primarily due to the instability of Sn-O active sites and slow water dissociation. In this work, a La-doped SnO catalyst is synthesized for efficient CO conversion to formate.
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