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Over the past two decades, per- and polyfluoroalkyl substances (PFASs) have emerged as worldwide environmental contaminants, calling out for sophisticated treatment, decomposition and remediation strategies. In order to mineralize PFAS pollutants, the incineration of contaminated material is a state-of-the-art process, but more cost-effective and sustainable technologies are inevitable for the future. Within this review, various methods for the reductive defluorination of PFASs were inspected. In addition to this, the role of mechanochemistry is highlighted with regard to its major potential in reductive defluorination reactions and degradation of pollutants. In order to get a comprehensive understanding of the involved reactions, their mechanistic pathways are pointed out. Comparisons between existing PFAS decomposition reactions and reductive approaches are discussed in detail, regarding their applicability in possible remediation processes. This article provides a solid overview of the most recent research methods and offers guidelines for future research directions.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7578953 | PMC |
http://dx.doi.org/10.3390/ijerph17197242 | DOI Listing |
mBio
August 2025
Biotechnology Institute, University of Minnesota Twin Cities, Saint Paul, Minnesota, USA.
There is intense interest in biodegrading fluorinated pesticides and other commercial products, some of which are per- and poly-fluorinated alkyl substances, or PFAS. Enzymatic carbon-fluorine bond cleavage via hydrolytic, reductive, and eliminative mechanisms generates an organic product, fluoride anion, and a proton. Biodegradation is typically determined by tracking the organic product using liquid chromatography-mass spectrometry (LC-MS) or the anion determined by a fluoride-specific electrode.
View Article and Find Full Text PDFAngew Chem Int Ed Engl
August 2025
Max-Planck-Institut für Kohlenforschung, Kaiser-Wilhelm-Platz 1, 45470, Mülheim an der Ruhr, Germany.
Herein, we report a catalytic defluorinative arylation of aldehydes with (per) A fluoroarenes facilitated by a pincer-based PheBox-Bi(I) under mild conditions. The protocol features various novel aspects in bismuth redox catalysis; namely, (1) a catalytic 1,2-aryl migratory insertion to forge a C─C bond, (2) an unprecedented example of multicomponent reaction through four elementary organometallic steps at a Bi center, (3) an unusual strategy for Bi(I) compounds regeneration via O─Si reductive elimination. Experimental and computational studies aided in dissecting the various mechanistic aspects of the bismuth redox cycle.
View Article and Find Full Text PDFSmall
July 2025
Department of Chemistry, School of Physics, Chemistry & Earth Sciences, University of Adelaide, Adelaide, SA, 5005, Australia.
Per- and poly-fluoroalkyl substances (PFAS) constitute a class of persistent organic pollutants that severely affect human health and the environment owing to their resistance to degradation by traditional water treatment methods. Semiconductor-assisted photocatalysis has the potential to be a green method to achieve complete mineralization of PFAS. Cadmium indium sulfide (CdInS) is an exciting photocatalytic material because of its high visible light harvesting capacity and high reduction potential.
View Article and Find Full Text PDFEnviron Sci Technol
August 2025
College of Environment, Zhejiang University of Technology, Hangzhou 310014, China.
The redox dynamics of estuarine sediments critically influence the environmental fate of antibiotics, yet the mechanistic pathways under oxygen-fluctuating conditions have been insufficiently elucidated. This study elucidates the dual-function role of pyrite in mediating the oxidative and reductive degradation of three model antibiotics (sulfamethoxazole, SMX; norfloxacin, NOR; and chlortetracycline, CTC) under aerobic and anaerobic conditions. Systematic batch experiments coupled with reactive oxygen species analysis reveal a dual-function mechanism for pyrite involving oxidative degradation via OH under aerobic conditions and reductive transformation under anaerobic conditions.
View Article and Find Full Text PDFWater Res
July 2025
State Key Laboratory of Urban-rural Water Resource and Environment, School of Environment, Harbin Institute of Technology, Harbin 150090, PR China.
Direct oxidation of per- and polyfluoroalkyl substances (PFAS) necessitates excessive energy or prolonged treatment, while reductive defluorination effectively cleaves C-F bonds. However, strict anaerobic requirements hinder its practical implementation. Herein, a photoelectrocatalytic-peroxymonosulfate (PEC-PMS) integrated system was developed for perfluorooctanoic acid (PFOA) degradation under ambient conditions.
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