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http://dx.doi.org/10.1038/s41408-020-00358-3 | DOI Listing |
Curr Oncol
August 2025
Department of Gastrointestinal Surgery, Peking University First Hospital, Beijing 100034, China.
Objective This study aimed to show the clinicopathological characteristics of large retroperitoneal liposarcoma (RLS) and to develop a customized nomogram model for patients with large RLS. Methods A total of 1735 patients diagnosed with RLS were selected from the public SEER database. Among them, 1113 patients with a maximum tumor diameter greater than 150 mm were included for further analysis.
View Article and Find Full Text PDFFront Immunol
August 2025
Department of Oncology, Shaoxing People's Hospital, The First Affiliated Hospital of Shaoxing University, Shaoxing, Zhejiang, China.
Background: Ferroptosis, a regulated form of cell death, has emerged as a critical modulator of melanoma's tumor progression and immune evasion. However, its integration with the tumor immune microenvironment (TME) and clinical prognostication remains underexplored. This study aims to construct a multi-omics framework combining ferroptosis-related signatures, immune infiltration patterns, and machine-learning approaches to stratify melanoma patients and guide therapeutic decision-making.
View Article and Find Full Text PDFNPJ Precis Oncol
August 2025
Department of Radiology, The Affiliated Hospital of Qingdao University, Qingdao, China.
Predicting the prognosis of bladder cancer remains challenging despite standard treatments. We developed an interpretable bladder cancer deep learning (BCDL) model using preoperative CT scans to predict overall survival. The model was trained on a cohort (n = 765) and validated in three independent cohorts (n = 438; n = 181; n = 72).
View Article and Find Full Text PDFDiscov Oncol
August 2025
Department of Pulmonary Oncology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Reseach Center for Cancer, Tianjin, 300060, China.
Purpose: Bladder cancer (BLCA) is a typical malignancy in the urinary tract, with a dismal survival rate and limited therapeutic options. There is a growing demand for clinically relevant biomarkers to effectively stratify prognosis. This study aims to develop a prognostic model utilizing mutation signatures and clinical characteristics to inform the clinical management of BLCA.
View Article and Find Full Text PDFTransl Cancer Res
July 2025
Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Tianjin, China.
Background: Neuroblastoma is a heterogeneous pediatric tumor with variable clinical outcomes. Current prognostic markers are insufficient to predict patient survival accurately, necessitating the identification of novel biomarkers and therapeutic targets. This study aimed to develop a robust prognostic model by integrating CRISPR screening data and transcriptomic profiles, and to explore its correlation with the tumor immune microenvironment.
View Article and Find Full Text PDF