Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Marine sponge-associated fungi are promising sources of structurally interesting and bioactive secondary metabolites. Great plenty of natural products have been discovered from spongeassociated fungi in recent years. Here reviewed are 571 new compounds isolated from marine fungi associated with sponges in 2010-2018. These molecules comprised eight different structural classes, including alkaloids, polyketides, terpenoids, meroterpenoids, etc. Moreover, most of these compounds demonstrated profoundly biological activities, such as antimicrobial, antiviral, cytotoxic, etc. This review systematically summarized the structural diversity, biological function, and future potential of these novel bioactive natural products for drug discovery.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.2174/1389557520666200826123248 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
HSQC-TOCSY fingerprinting-guided isolation of undescribed glycosides and scalemic pentaketides with neuroprotective activity from a mesophotic zone Ircinia sponge-associated fungus, Acremonium sp. NBUF233.
Fitoterapia
August 2025
Li Dak Sum Yip Yio Chin Kenneth Li Marine Biopharmaceutical Research Center, Health Science Center, Ningbo University, Ningbo 315211, Zhejiang, China; State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing 10019, China. Electronic address:
HSQC-TOCSY fingerprinting-guided fractionation led to the discovery of three undescribed pentaketide, hexaketide, and monocyclofarnesol-type sesquiterpenoid glycosides, namely acremols A-C (1-3), along with new scalemic pentaketides (+)-4 and (-)-4, designated as (+) and (-)-acremols D, from fungus Acremonium sp. NBUF233 associated with a mesophotic zone Ircinia sponge. The structural elucidation was achieved through comprehensive spectroscopic data analysis combined with chemical degradation.
View Article and Find Full Text PDFFunctional Genomic Characteristics of Marine Sponge-Associated MI-G.
Microorganisms
August 2025
Marine Biotechnology Laboratory and State Key Laboratory of Microbial Metabolism, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, China.
The genus comprises a group of marine, gram-negative bacteria known for their remarkable ability to adapt to a variety of environments. Therefore, this study aimed to investigate the genetic diversity and metabolic characteristics of MI-G and three reference strains by genomic and comparative genomic analysis. Compared to free-living reference strains, the lower GC content, higher number of strain-specific genes, pseudogenes, unique paralogs, dispensable genes, and mobile gene elements (MGEs) such as genomic islands (GIs) and insertion sequence (IS) elements, while the least number of CAZymes, indicates that MI-G may be a facultative sponge-symbiont.
View Article and Find Full Text PDFGenomic Characterization of Marine Strain SC-M1C: Potential Genetic Adaptations and Ecological Role.
Microorganisms
August 2025
Department of Microbiology & Immunology, Faculty of Pharmacy, Suez Canal University, Ismailia 41522, Egypt.
() is a coagulase-negative species primarily associated with the degradation of organic matter, contributing to nutrient cycling in natural environments. This species has been mainly studied in clinical and terrestrial contexts, with no previous reports of its presence in marine environments. In this study, we report the first isolation of from a marine habitat.
View Article and Find Full Text PDFIn-vitro and bioinformatic studies of bioactive compounds from Oceanimonas sp. JM-AZM31 and Lysinibacillus fusiformis JM-AZM37 of sponge-associated marine bacteria from a mangrove habitat in Southeast Sulawesi.
J Genet Eng Biotechnol
September 2025
Department of Biology, Faculty of Mathematics and Natural Science, Halu Oleo University, Kendari, Southeast Sulawesi, Indonesia. Electronic address:
The ongoing quest for novel therapeutic agents has directed attention toward bioactive compounds derived from sponge-associated bacteria. This study focuses on sponge symbiont bacteria from the mangrove ecosystems in Tanjung Tiram, Southeast Sulawesi, which have not yet been reported for their potential antibacteria, anti-inflammatory, antioxidant, and anti-diabetic activities. The screening of marine bacterial isolates was performed using a series of assays: disc diffusion method to assess antibacterial activity, protein denaturation to assess anti-inflammatory properties, DPPH free radical scavenging to evaluate antioxidant capacity, and α-Glucosidase inhibition for anti-diabetic activity, followed by in silico validation.
View Article and Find Full Text PDFDiversity and composition of sponge-associated microbiomes from Korean sponges revealed by full-length 16S rRNA analysis.
Sci Rep
August 2025
Department of Biomedical Science and Engineering, Konkuk University, Seoul, 05029, Republic of Korea.
Marine sponges host diverse and specialized microbial communities that serve essential functions in nutrient cycling, ecosystem stability, and biotechnological applications. This study investigates the diversity and composition of sponge-associated microbiomes from eight sponge species collected in Chuksan Harbor, South Korea, using full-length 16S rRNA sequencing and amplicon sequence variant (ASV)-based methods. Our results demonstrate that each sponge species harbors distinct and highly structured microbial communities.
View Article and Find Full Text PDF