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Background: Reading relies on ocular motor function, requiring sequential eye movements (forward and regressive saccades). Binocularly discordant input from a dense congenital or infantile cataract is associated with ocular motor dysfunction and may affect the development of reading ability. The purpose of this study was to assess silent, binocular reading in children treated for unilateral congenital or infantile cataract.
Methods: Twenty school-age children (age range, 7-13 years) treated for unilateral congenital (n = 9) or infantile (n = 11) cataract and 49 age-similar control children silently read a grade-appropriate paragraph during binocular viewing. Reading rate (words/min) and the number of forward and regressive saccades (per 100 words) were recorded using the ReadAlyzer.
Results: Reading rate in children treated for a unilateral cataract did not differ significantly from controls (174 ± 59 words/min vs 195 ± 54 words/min; P = 0.1). However, they did have significantly more forward saccades (101 ± 33 saccades/100 words vs 87 ± 21 saccades/100 words; P = 0.03) but not regressive saccades (21 ± 14 saccades/100 words vs 16 ± 8 saccades/100 words; P = 0.1) compared with controls. Reading rate was not related to cataract type (congenital vs infantile), visual acuity outcome (poor vs good), or sensory fusion (fail vs pass; all P ≥ 0.1).
Conclusions: Reading rate of children treated for a dense unilateral cataract did not differ from that of controls. Increased forward saccades during reading may be due to fixation instability associated with fusion maldevelopment nystagmus prevalent in children following cataract extraction.
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http://dx.doi.org/10.1016/j.jaapos.2020.04.009 | DOI Listing |
Front Oncol
August 2025
Department of Pathology, West China Hospital, Sichuan University, Chengdu, China.
In this study, we retrospectively analyzed the clinicopathological features of a case of hepatic infantile hemangioma (HIH) that malignantly transformed into hemangiosarcoma. HIH, a congenital disease, is the most common benign tumor of the liver in children, and its malignant transformation into hepatic angiosarcoma (HAS) is rare. HIH expresses markers of vascular origin and specifically expresses glucose transporter protein isoform 1.
View Article and Find Full Text PDFRadiol Case Rep
November 2025
Department of Pediatrics and Child Health, Hawassa University College of Medicine and Health science, Hawassa, Ethiopia.
Klippel-Trenaunay syndrome (KTS) is a rare congenital disorder characterized by a triad of clinical features: capillary malformations, venous varicosities, and hypertrophy of soft or bony tissues. This case report presents a 1-year-old infant diagnosed with KTS, exhibiting multifocal pelvic, gluteal, and thigh macrocystic lymphatic malformations alongside significant limb overgrowth. The diagnosis was confirmed through clinical evaluation and advanced imaging techniques, including Doppler ultrasound and CT angiography.
View Article and Find Full Text PDFJ AAPOS
August 2025
Department of Ophthalmology and Vision Science, Eye & ENT Hospital of Fudan University, Shanghai, China; Key laboratory of Myopia and Related Eye Diseases, Chinese Academy of Medical Sciences, Shanghai, China; Shanghai Key Laboratory of Visual Impairment and Restoration, Shanghai, China. Electronic
We report a rare case of restrictive strabismus in a pediatric patient who was initially misdiagnosed with Duane retraction syndrome (DRS) because she had large-angle exotropia, restricted adduction, globe retraction, narrowing of the palpebral fissure, and downshoot on attempted adduction. Notably, the parents first observed strabismus at 12 months of age, with photographs taken before 6 months of age revealing no ocular misalignment. Despite the absence of typical inflammatory signs, the temporal discrepancy, characterized by delayed onset inconsistent with congenital DRS, prompted further investigation.
View Article and Find Full Text PDFBMC Gastroenterol
August 2025
Department of Endocrinology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jiefang Avenue, Wuhan, Hubei, China.
Background: The Notch signaling pathway plays a crucial role in intrahepatic bile duct development. Here, we aimed to investigate the effect of the Notch receptor, NOTCH2, on intrahepatic bile duct development to better understand congenital intrahepatic bile duct dysplasia.
Results: Estradiol increased NOTCH2 and its downstream proteins expression, which promoted the differentiation of hepatoblasts into intrahepatic cholangiocytes and the development of intrahepatic bile ducts by upregulating the Notch signaling pathway.
BMC Med Genomics
August 2025
Student Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Background: Neurodevelopmental disorders (NDDs) are a heterogeneous group of conditions characterized by impairments in motor, cognitive, and behavioral functions. Despite advances in genomic sequencing, the genetic basis of many NDDs remains unexplored. CCDC82 encodes a coiled-coil domain-containing protein with an unknown function in the nervous system.
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