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We describe a new technique for non-contact corneal and lenticular microscopy. It is based on fundus retro-reflection and back-illumination of the crystalline lens and cornea. To enhance phase-gradient contrast, we apply asymmetric illumination by illuminating one side of the fundus. The technique produces micron-scale lateral resolution images across a 1 mm diagonal field of view in the central cornea. We show representative images of the epithelium, the subbasal nerve plexus, large stromal nerves, dendritic immune cells, endothelial nuclei, and the anterior crystalline lens, demonstrating the potential of this instrument for clinical applications.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7316012 | PMC |
http://dx.doi.org/10.1364/BOE.391815 | DOI Listing |
Invest Ophthalmol Vis Sci
August 2025
Centre for Vision and Eye Research, Queensland University of Technology, Brisbane, Queensland, Australia.
Purpose: The purpose of this study was to determine the (i) contributions of refracting components to ocular aberrations and (ii) compensation effects exhibited by these components in keratoconus.
Methods: Right eyes of 14 keratoconus and 20 control participants were analyzed using 5 mm pupils. Ocular aberrations were measured with a Hartmann-Shack aberrometer.
Medicine (Baltimore)
August 2025
Department of Ophthalmology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China.
Rationale: Necrotic scleral melting presents a significant therapeutic challenge, especially when complicated by concurrent conditions like refractory glaucoma. Conventional repair materials often have limitations. This case report aimed to evaluate the long-term efficacy and safety of a novel approach: utilizing an allogeneic corneal intrastromal lenticule (typically discarded after small incision refractive lenticule extraction surgery) combined with an autologous conjunctival graft for repairing necrotic scleral melting in a complex patient with glaucoma.
View Article and Find Full Text PDFAnn Med Surg (Lond)
August 2025
Ophthalmology department "A", Ibn Sina University Hospital (hôpital des spécialités), Mohammed V University, Rabat, Morocco.
Introduction And Importance: Angle closure in pseudophakic patients with posterior chamber implants is a rare but serious complication following cataract surgery, often stemming from malignant glaucoma or pseudophakic pupillary block. While typically observed shortly after surgery, rare instances have been documented months to years postoperatively. This condition is characterized by the anterior displacement of the lens-iris-diaphragm complex.
View Article and Find Full Text PDFSci Rep
August 2025
Imaging, Biomechanics and Mathematical Modeling Solutions Lab, Narayana Nethralaya Foundation, Bangalore, India.
Differences in lenticule shapes may impact on the design of future presbyopic treatments with lenticule surgery. Hence, the objective of this study was to assess the depth of field of eyes after smooth Incision Lenticular Keratomileusis (SILK) surgery for refractive correction of myopia. In this study, patients who underwent SILK surgery were included.
View Article and Find Full Text PDFCureus
June 2025
Ophthalmology, Cornea and Refractive Surgery, University of Utah School of Medicine, Salt Lake City, USA.
Purpose To provide an updated characterization of the reasons for laser-assisted in situ keratomileusis (LASIK) non-candidacy. Methods A retrospective chart review was conducted on 648 patients (648 right eyes) who presented for LASIK evaluation at a refractive surgery center in Draper, UT, between November 2022 and April 2023. Age, spherical equivalent (SEQ), and keratometry measurements were compared between LASIK candidates and non-candidates.
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