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Article Abstract
Tumor-infiltrating lymphocytes (TILs) and postoperative chemotherapeutics interact in the tumor micro-environment. This interaction has not been well investigated in gastric cancer. A total of 129 patients were divided into high or low TILs based on the median number of positive CD3 and FoxP3 T cells, which was assessed by immunocytochemistry. Cox regression analysis showed that the stage III disease with shorter overall survival was significant. The analysis showed that high numbers of CD3 or FoxP3 T cells have better clinical outcomes in FOLFOX-treated patients. High CD3 and FoxP3 T-cell infiltration was associated with better clinical outcomes in patients with gastric cancer treated with FOLFOX, suggesting TILs incorporated into algorithms to improve the therapeutic efficacy of optimal chemotherapy.
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| http://dx.doi.org/10.2217/pgs-2019-0102 | DOI Listing |
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