Use of an anatomical atlas in real-time EIT reconstructions of ventilation and pulsatile perfusion in preterm infants.

Electrical impedance tomography (EIT) is a bedside imaging technique in which voltage data arising from current applied on electrodes is used to compute images of admittivity in real time. Due to the severe ill-posedness of the inverse problem, good spatial resolution poses a challenge in EIT. Conversely, the temporal resolution is high, facilitating dynamic bedside imaging.

Provision of Person-Centered Contraceptive Care to Adolescents: Results From a National Survey of Family Planning Clinics.

Study Objective: Access to contraceptive services is essential for adolescents to pursue sexual and reproductive well-being. Publicly supported family planning clinics are critical reproductive health safety net providers and are an essential source of contraceptive care for adolescents. Contraceptive care for adolescents should be centered on their needs to ensure reproductive autonomy.

Telehealth use among publicly funded family planning clinics in the United States: Results from a national survey.

Objectives: This study aimed to examine the scope of telehealth contraceptive services at publicly supported family planning clinics.

Study Design: We surveyed a sample of 446 publicly supported family planning clinics in the United States.

Results: Most clinics offer some services via telehealth, but provision varies widely by clinic type, with Planned Parenthood clinics offering telehealth most frequently, and by service, with certain contraceptive services, sexually transmitted infections (STI) testing and treatment, and medication abortion less frequently available than messaging services.

The Impact of a Novel Transfer Process on Patient Bed Days and Length of Stay: A Five-Year Comparative Study at the Mayo Clinic in Rochester and Mankato Quaternary and Tertiary Care Centers.

This study evaluated the impact of parallel-level patient transfers on bed utilization efficiency within the Mayo Clinic Health System in Southern Minnesota, focusing on optimizing resources across tertiary and critical access hospitals. A retrospective analysis of 179,066 Emergency Department visits (2018-2022) was conducted, with ~2% involving parallel-level transfers for observation or admission. Machine learning was utilized to identify patients suitable for parallel transfers based on demographics, comorbidities, and clinical factors.

Effects of the Decision on Publicly Supported Sexual and Reproductive Health Clinics: Results from a National Study.

Abortion bans and restrictions may have ripple effects on other forms of sexual and reproductive health care such as contraception provision. While only a small proportion of publicly supported sexual and reproductive health clinics offer abortion care, many are likely experiencing direct and indirect impacts of the June 2022 Supreme Court decision. We analyzed data from a national survey of 446 clinics conducted between November 2022 and December 2023 to understand provision of pregnancy options counseling, miscarriage management, and abortion, as well as perceived changes in patient demand for contraception, abortion referrals, and pregnancy options counseling.

Prognostic significance of estrogen receptor expression and estrogen signaling in endometrial carcinomas of no specific molecular profile: A comprehensive molecular and pathologic analysis.

Introduction: Copy number-low (CNL) endometrial cancer (EC), also known as no specific molecular profile (NSMP), is the most heterogeneous molecular subtype. In this study, we evaluated the prognostic significance of estrogen receptor (ER) and PTEN expression in primary untreated CNL/NSMP ECs across all histologic subtypes to further refine risk stratification within this heterogeneous group.

Methods: We identified a total of 1835 CNL/NSMP ECs that underwent clinical sequencing of 410-468 cancer-related genes.

Peritoneal washings analysis in endometrial cancer: Comparison of somatic mutation detection with panel sequencing and traditional cytology.

Objectives: The prognostic significance of positive pelvic washings in endometrial cancer (EC) remains unknown, and little data exist regarding washings as a source of genetic information in relation to a patient's tumor. We sought to assess the feasibility of identifying EC mutations in peritoneal washings.

Methods: Peritoneal washings from 21 biopsy-confirmed newly diagnosed patients with EC across disease stages between 09/2018 and 07/2019 were collected.

Assessing the Provision of Person-Centered Contraceptive Care at Publicly Supported Clinics Providing Contraceptive Services in the United States.

Introduction: We sought to understand the extent to which the contraceptive care provided at publicly supported family planning clinics in the United States aligns with aspects of person-centered care.

Materials And Methods: We conducted a descriptive study with a national sample of U.S.

Molecular subtypes and genomic landscape of undifferentiated and dedifferentiated endometrial cancer.

Objective: Undifferentiated and dedifferentiated endometrial carcinomas are rare and clinically aggressive variants of the disease. We sought to define the molecular subtypes and genetic alterations affecting cancer-related genes of these rare histologic endometrial cancer types.

Methods: Patients with undifferentiated/dedifferentiated endometrial cancer subjected to clinical tumor-normal panel sequencing between January 1, 2014, to June 1, 2023, were retrospectively identified, and relevant demographic and clinicopathologic data were extracted from medical records.

Multi-center, international endometrial cancer consortium highlights.

The multi-center, international consortium on endometrial cancer held in January 2025 at Mayo Clinic in Rochester, Minnesota brought together leading experts in gynecologic oncology to explore the latest advancements in the understanding, diagnosis, and treatment of endometrial cancer. Discussions centered on key topics, including updates in molecular testing and disease staging, emerging treatment strategies for advanced and recurrent disease, fertility-sparing management, and critical pathology challenges, particularly, the assessment of lympho-vascular space invasion. Each topic was examined in dedicated working group sessions, fostering in-depth exchanges to identify research priorities and develop actionable strategies.

The genomic landscape of distant metastatic endometrial cancer.

Objective: The molecular underpinnings of primary treatment-naïve endometrial carcinoma (EC) are well described. Here we sought to characterize the genomic landscape of distant metastatic EC.

Methods: Distant metastatic ECs from a total of 1888 cases subjected to a clinical panel sequencing between 4/2015 and 6/2020 were identified, and their genomic profiles, affected pathways and actionable alterations were compared to those of 711 primary ECs.

Time of Flight Transmission Mode Ultrasound Computed Tomography With Expected Gradient and Boundary Optimization.

Objective: Quantitative time of flight in transmission mode ultrasound computed tomography (TFTM USCT) is a promising, cost-effective, and non-invasive modality, particularly suited for functional imaging. However, TFTM USCT encounters resolution challenges due to path information concentration in specific medium regions and uncertainty in transducer positioning. This study proposes a method to enhance resolution and robustness, focusing on low-frequency TFTM USCT for pulmonary imaging.

Effect of substantial lymphovascular space invasion on location of first disease recurrence in surgical stage I endometrioid endometrial adenocarcinoma.

Objective: Lymphovascular invasion can predict nodal spread and recurrence in endometrioid endometrial cancer; however, the impact of lymphovascular invasion quantification on local versus distant recurrence in surgically staged patients has not yet been established.

Methods: This multicenter, retrospective cohort study included surgically staged patients with International Federation of Obstetrics and Gynecology 2009 stage I node-negative endometrioid endometrial cancer. Patients were treated between January 2012 and December 2019 at 2 tertiary cancer centers.

Simultaneous Acquisition of EIT and ECG Signals on Active EIT Electrodes.

Objective: This paper introduces a new method of simultaneous acquisition of electrocardiogram (ECG) signals and electrical impedance tomography (EIT) measurements on active electrodes, i.e. electrodes that are applying current, in an EIT system.

Feasibility of Electric Impedance Tomography in the Assessment of Lung Perfusion and Ventilation in Congenital Pulmonary Vein Stenosis.

Pulmonary vein stenosis (PVS) is a complex disease that requires repeated percutaneous interventions. Electrical impedance tomography (EIT) is a functional imaging technique that provides real-time images of pulmonary perfusion and ventilation. We aimed to determine the feasibility of EIT to evaluate ventilation/perfusion in PVS before and after catheter-based interventions.

RELEVANT-C study: patient-reported prevalence of lower extremity lymphedema after sentinel lymph node mapping vs lymphadenectomy after surgery for early-stage cervical cancer.

Objective: To compare the prevalence of patient-reported lower extremity lymphedema and evaluate patient-reported quality of life after sentinel lymph node mapping vs comprehensive lymphadenectomy with or without sentinel lymph node mapping for the surgical management of early-stage cervical cancer.

Methods: In July 2022, we mailed a survey that included a validated 13-item lower extremity lymphedema screening questionnaire to patients who underwent lymph node evaluation at the time of primary surgery for the 2018 International Federation of Gynecology and Obstetrics stage IA1 to IIB cervical cancer between January 1, 2006, and January 31, 2019. We excluded patients diagnosed with lower extremity lymphedema prior to surgery and those who answered ≤6 survey items, and we carried out 2 group comparisons: sentinel lymph node mapping vs lymphadenectomy with or without sentinel lymph node mapping, and patients with lower extremity lymphedema vs patients without.

Three-Dimensional Electrical Impedance Imaging During Spontaneous Breathing Trials in Patients With Acute Hypoxic Respiratory Failure: A Pilot Study.

The purpose of this work is to evaluate the feasibility of lung imaging using 3D electrical impedance tomography (EIT) during spontaneous breathing trials (SBTs) in patients with acute hypoxic respiratory failure. EIT is a noninvasive, nonionizing, real-time functional imaging technique, suitable for bedside monitoring in critically ill patients. EIT data were collected in 24 mechanically ventilated patients immediately preceding and during a SBT on two rows of 16 electrodes using a simultaneous multicurrent source EIT system for 3D imaging.

Role of MRI in Assessing the Feasibility of Fertility-Sparing Treatments for Early-Stage Endometrial and Cervical Cancers.

Fertility-sparing treatment (FST) has become a key aspect of managing gynecologic cancers in reproductive-age patients who wish to preserve fertility. Several leading clinical societies, including the European Society of Gynecological Oncology, the European Society for Radiotherapy and Oncology, the European Society of Pathology, and the European Society of Human Reproduction and Embryology, have published evidence-based guidelines on fertility-sparing strategies and post-treatment surveillance of patients with early-stage gynecologic cancers, in particular endometrial and cervical cancers. These guidelines highlight MRI as essential to initial patient selection and follow-up.

A digital, decentralized trial of exercise therapy in patients with cancer.

We developed and evaluated the Digital Platform for Exercise (DPEx): a decentralized, patient-centric approach designed to enhance all aspects of clinical investigation of exercise therapy. DPEx integrated provision of a treadmill with telemedicine and remote biospecimen collection permitting all study procedures to be conducted in patient's homes. Linked health biodevices enabled high-resolution monitoring of lifestyle and physiological response.

Lymph node metastases in endometrial carcinoma: A modern assessment in the era of sentinel lymph node mapping and molecular subtyping.

Objective: To examine the risk of sentinel lymph node (SLN) metastases in apparent uterine-confined endometrial cancer (EC) using molecular classification with clinicopathologic features and assess oncologic outcomes by molecular subtypes with micro- or macro-metastases in SLN.

Methods: Patients undergoing surgical staging for presumed uterine-confined EC of any histology, with successful bilateral SLN mapping were included. Primary tumors were assigned molecular subtypes using a published algorithm.