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Advanced technologies, such as reverse osmosis (RO), allow the reuse of treated wastewater for direct or indirect potable use. However, even highly efficient RO systems produce ~10-15% highly contaminated concentrate as a byproduct. This wastewater RO concentrate (WWROC) is very rich in metal ions, nutrients, and hard-to-degrade trace organic compounds (TOrCs), such as pharmaceuticals, plasticizers, flame retardants, and detergents, which must be treated before disposal. WWROC could be up to 10 times more concentrated than secondary effluent. We examined the efficiency of several advanced oxidation processes (AOPs) on TOrC removal from a two-stage WWROC matrix in a pilot wastewater-treatment facility. WWROC ozonation or UV irradiation, with HO addition, demonstrated efficient removal of TOrCs, varying between 21% and over 99% degradation, and indicating that radical oxidation (by HO·) is the dominant mechanism. However, AOPs are not sufficient to fully treat the WWROC, and thus, additional procedures are required to decrease metal ion and nutrient concentrations. Further biological treatment post-AOP is also highly important, to eliminate the degradable organic molecules obtained from the AOP.
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http://dx.doi.org/10.3390/ma13122785 | DOI Listing |
Nat Metab
September 2025
Department of Bioinformatics and Biochemistry, Braunschweig Integrated Centre of Systems Biology (BRICS), Technische Universität Braunschweig, Braunschweig, Germany.
Itaconate is an immunomodulatory metabolite that alters mitochondrial metabolism and immune cell function. This organic acid is endogenously synthesized by tricarboxylic acid (TCA) metabolism downstream of TLR signalling. Itaconate-based treatment strategies are under investigation to mitigate numerous inflammatory conditions.
View Article and Find Full Text PDFInt J Biol Macromol
September 2025
School of Life Science and Technology, Wuhan Polytechnic University, Wuhan, 430023, China. Electronic address:
Quantum dots, with their superior intrinsic fluorescence and photostability, are emerging as a promising option for cancer gene therapy, diagnosis, and imaging. However, low gene delivery efficiency, insufficient targeting, and responsiveness remain challenges. To address these issues, PEI-based carbon quantum dots (CPNCs) were constructed by crosslinking polyethylenimine quantum dots (PQDs) with carbon quantum dots (CQDs) via disulfide bonds.
View Article and Find Full Text PDFFood Chem
September 2025
Shanghai Frontiers Science Center of Drug Target Identification and Delivery, National Key Laboratory of Innovative Immunotherapy, Engineering Research Center of Cell & Therapeutic Antibody, School of Pharmaceutical Sciences, Shanghai Jiao Tong University, Shanghai 200240, China. Electronic address:
The residues of antiviral drugs acyclovir (ACV), penciclovir (PCV) and ganciclovir (GCV) in foods, particularly in ready-to-eat products, pose a significant threat to human health, making it urgent to develop a rapid and sensitive method for their detection. Herein, we designed a novel magnetic molecularly imprinted three-dimensional covalent organic framework (MICOF@FeO) for selective extraction of these antiviral drugs from complicated food matrix. The prepared MICOF@FeO integrates molecular recognition ability, 3D COF structural advantages and magnetic responsiveness, providing high selectivity, large adsorption capacity and facile operation for magnetic solid-phase extraction (MSPE).
View Article and Find Full Text PDFJ Hazard Mater
September 2025
College of Geography and Environmental Sciences, Zhejiang Normal University, Jinhua 321004, China.
Room-temperature crystallization of a cobalt-aminoterephthalate framework (CoBDC-NH) directly on 3D-printed polylactic acid (PLA) yields a super-wetting membrane that reconciles permeability and selectivity in oil-water separation. The ambient-pressure route dispenses with conventional hydrothermal steps and preserves the PLA architecture. Molecular dynamics (MD) combined with density-functional (DFT) calculations reveal that NaOH activation exposes carboxylate sites, while trace polyvinylpyrrolidone amplifies van der Waals forces, uniformly dispersing Co nuclei and anchoring the metal-organic framework (MOF) layer.
View Article and Find Full Text PDFJ Chromatogr A
August 2025
Department Guangzhou Key Laboratory of Analytical Chemistry for Biomedicine, GDMPA Key Laboratory for Process Control and Quality Evaluation of Chiral Pharmaceuticals, School of Chemistry, South China Normal University, Guangzhou 510006 Guangdong, PR China. Electronic address:
Zearalenone (ZEN), a mycotoxin produced by fungi of the genus Fusarium, is widely present in animal feeds and human foods, posing a serious hazard to human health. Herein, a zearalenone aptamer-functionalized magnetic metal-organic framework material (ZEN-Apt@MMIL-100(Fe)) was constructed and applied for the rapid enrichment of ZEN, coupled with high-performance liquid chromatography (HPLC) for ultrasensitive detection. By a self-templating method, magnetic MIL-100(Fe) was formed by self-assembly of sodium citrate-modified FeO particles as nuclei with homobenzoic acid, which was bonded to amino-modified zearalenone nucleic acid aptamer via amide reaction to realize a specific recognition function.
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