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Background: Diarrheal and acute respiratory infections remain a major cause of death in developing countries especially among children below 5 years of age. About 80% of all hospital attendances in Kenya can be attributed to preventable diseases and at least 50% of these preventable diseases are linked to poor sanitation. The purpose of this study was to assess the impact of a community-based health education program, called Familia Nawiri, in reducing the risk of diarrhea and respiratory infections among people living in three rural Kenyan communities.
Methods: Cases were defined as patients attending the health facility due to diarrhea or a respiratory infection while controls were patients attending the same health facility for a non-communicable disease defined as an event other than diarrhea, respiratory infection. Adjusted odds ratios (ORs) with 95% confidence intervals (CIs) were calculated using a logistic regression model to assess the risk of diarrheal or respiratory infection in association with exposure to the health education program.
Results: There were 324 cases and 308 controls recruited for the study with 57% of the cases and 59% of the controls being male. Overall, 13% of cases vs. 20% of control patients were exposed to the education program. Participants exposed to the program had 38% lower odds of diarrhea and respiratory infections compared to those not exposed to the program (adjusted OR 0.62, 95% CI 0.41-0.96). A similar risk reduction was observed for participants in the study who resided in areas with water improvement initiatives (adjusted OR 0.65, 95% CI 0.47-0.90). Variables in the adjusted model included water improvement projects in the area and toilet facilities.
Conclusion: Findings from this study suggest participants exposed to the education program and those residing in areas with water improvement initiatives have a reduced risk of having diarrhea or respiratory infection.
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http://dx.doi.org/10.1186/s12889-020-08728-z | DOI Listing |
Microb Pathog
September 2025
Laboratory of Pharmacobiology, Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing 100193, China. Electronic address:
Lipid profile of spleen and bursa of Fabricius (BF) during acute infection remains unknown. Acute infection models of porcine reproductive and respiratory syndrome virus (PRRSV), porcine epidemic diarrhea virus (PEDV) and Eimeria tenella (ET) were developed, and spleen samples with African swine fever virus (ASFV) or not were collected. Spleen and BF were examined and characteristic microscopic lesions were observed.
View Article and Find Full Text PDFPLoS Pathog
September 2025
Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), Shanghai Institute of Infectious Disease and Biosecurity, Shanghai Frontiers Science Center of Pathogenic Microorganisms and Infection, School of Basic Medical Sciences, Shanghai Medical College, Fudan University, Shanghai, China.
Coronaviruses, including SARS-CoV-2, rely on host factors for their replication and pathogenesis, while hosts deploy defense mechanisms to counteract viral infections. Although numerous host proviral factors have been identified, the landscape of host restriction factors and their underlying mechanisms remain less explored. Here, we conducted genome-wide CRISPR knockout screens using three distinct coronaviruses-SARS-CoV-2, HCoV-OC43 (a common cold human virus from the genus Betacoronavirus) and porcine epidemic diarrhea virus (Alphacoronavirus) to identify conserved host restriction factors.
View Article and Find Full Text PDFIDCases
August 2025
Department of Medicine, Hadassah Medical Organization, Faculty of Medicine, Hebrew University of Jerusalem, Israel.
Group A Strep (GAS) infection associated with intrauterine devices (IUDs) is rare and only sporadically described following IUDs removal. We present a unique case of toxic shock syndrome presenting with pyogenic ascites following IUD removal in a 29 year old otherwise healthy woman. Upon admission, the patient primarily complained of abdominal pain and diarrhea and was found to have acute kidney injury.
View Article and Find Full Text PDFAMB Express
August 2025
College of Veterinary Medicine, Northeast Agricultural University, No.600, Changjiang Road, XiangFang District, Harbin, 150030, Heilongjiang Province, People's Republic of China.
Unlabelled: In the prevention and control of animal diseases, synbiotics combine the principles of probiotics and prebiotics, which play crucial roles in reducing intestinal disorders, such as diarrhea and indigestion, enhancing immune function, and decreasing the incidence of respiratory diseases in livestock and poultry. Following the confirmation of the prebiotic activity of lentinan, this study aimed to use microencapsulation technology to prepare synbiotics composed of () and lentinan. The optimal preparation process for the synbiotic microcapsules was determined through single-factor, orthogonal, and response surface experiments.
View Article and Find Full Text PDFEnviron Res
August 2025
Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, United Kingdom. Electronic address:
Background: Although climate change poses increasing risks to child health, particularly through temperature extremes, epidemiological evidence on its impact on child mortality is still limited. This study investigated the short-term effects of ambient temperatures (heat and cold) on under-five mortality in Brazil.
Methods: We conducted a space-time-stratified case-crossover study across 5570 Brazilian municipalities from 2000 to 2019, using data from the Brazilian Mortality Information System and from the Brazilian Daily Weather Gridded Data (BR-DWGD).