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Fungal disease is an important factor restricting the healthy development of Gastrodia elata industry. The control of fungal disease in G. elata is an important issue in production. This paper makes a detailed investigation on the current situation of G. elata disease in China through statistics on the failure rate, rotten pit rate and occurrence rate of G. elata disease in the main producing areas of China. It was found that G. elata disease was mainly infected from the top bud and junction, causing the occurrence rate of disease was 6%-17%, and the yield decreased by 10%-30%. The 23 dominant fungi were isolated from 18 typical G. elata disease samples. Through identification of colony morphology, mycelium morphology, spore morphology and genetic characteristics, they were finally identified as 13 species, belonging to 7 families and 7 genera. Trichoderma harzianum, Ilyonectria sp. and Ilyonectria destructans are the most frequently separated. Their isolation frequency were 22.22%,16.67%,16.67% respectively. Ilyonectria sp. and I. destructans were the first time isolated from G. elata disease samples. They may be the main pathogens causing soil-borne diseases of G. elata. T. harzianum has certain potential as Gastrodia biocontrol bacteria. This study can provide a theoretical basis for the research and development of control technology of Gastrodia fungi disease.
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http://dx.doi.org/10.19540/j.cnki.cjcmm.20191204.108 | DOI Listing |
J Ethnopharmacol
September 2025
Key Laboratory of Basic Pharmacology of Ministry of Education and Joint International Research Laboratory of Ethnomedicine of Ministry of Education, Zunyi Medical University, Zunyi, Guizhou Province, China. Electronic address:
Ethnopharmacological Relevance: Gastrodia elata, also known as Chijian, belongs to the Orchidaceae family of plants. The "Compendium of Materia Medica" records that Gastrodia elata treats "confused speech, excessive fear, and loss of willpower". Gastrodin (GAS) is the main bioactive component of Gastrodia elata.
View Article and Find Full Text PDFPhytomedicine
September 2025
State Key Laboratory of Southwestern Chinese Medicine Resources, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China; Key Laboratory of the Ministry of Education for Standardization of Chinese Medicine, Chengdu University of Traditional Chinese Medicine, Che
Background: Ulcerative colitis (UC), a chronic idiopathic inflammatory bowel disorder, presents persistent therapeutic challenges in clinical management. Gastrodin (GAS) is an active compound isolated from traditional Chinese medicine Gastrodia elata (Tianma), exhibits robust anti-inflammatory bioactivity. However, the role of GAS in UC has not been thoroughly studied.
View Article and Find Full Text PDFBiomedicines
August 2025
Department of Biomedical Sciences, Faculty of Medicine, Catholic University Our Lady of Good Counsel, 1000 Tirana, Albania.
: Parkinson's disease (PD) is a complex nervous system disorder characterized by the gradual loss of dopaminergic neurons, leading to disturbances in movement, such as resting tremors, rigidity, bradykinesia, or akinesia; postural issues; and freezing (motor block). Due to the limitations and side effects of current pharmacological treatments, there is a growing interest in investigating the therapeutic potential of medicinal plants. : A semi-systematic review was conducted using PubMed, Web of Science, and Scopus as main databases, identifying original research articles, systematic reviews, and relevant preclinical or clinical studies published between January 2000 and December 2024.
View Article and Find Full Text PDFSci Rep
August 2025
The First Clinical Medical College of Shandong University of Traditional Chinese Medicine, 4655 Gu Yunhu Road, Changqing District, Jinan City, 250355, Shandong Province, China.
This study aims to screen for common differentially expressed genes (DEGs) related to Parkinson's disease (PD) and circadian rhythm (CR) through bioinformatics methods, and further analyze their potential molecular mechanisms and traditional Chinese medicine-targeted components, providing new targets and drug development ideas for the treatment of PD. This study first obtained PD-related microarray data from the GEO database to screen for differentially expressed genes. Using the WGCNA algorithm to construct a gene co-expression network and filter key module genes.
View Article and Find Full Text PDFInt J Mol Sci
August 2025
Pharmacy School, Guizhou University of Traditional Chinese Medicine, Guiyang 550025, China.
Blume is an important medicinal orchid, yet its large-scale cultivation is increasingly threatened by fungal diseases. The 4-coumarate-CoA ligase (4CL) gene family directs a key step in phenylpropanoid metabolism and plant defence, but its composition and function in have not been investigated. We mined the genome for 4CL homologues, mapped their chromosomal locations, and analysed their gene structures, conserved motifs, phylogenetic relationships, promoter cis-elements and codon usage bias.
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