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Study Design: A retrospective study.
Objective: To assess the long-term results of zero-profile spacer for 3-level anterior cervical discectomy and fusion (ACDF).
Summary Of Background Data: Although widely used, there are still controversies about the long-term results of zero-profile spacer, especially in multilevel cases.
Methods: Cases received 3-level ACDF for cervical spondylotic myelopathy (CSM) using either zero-profile spacer (n = 27) (ZP Group), or plate and cages (n = 34) (PC Group), and with 5-year follow-up were reviewed. Neurological function and life quality were assessed by modified Japanese Orthopaedic Association (mJOA) score, Neck Disability Index (NDI), and Short-Form 36 (SF-36) score. Disc height, cervical lordosis, fusion rate, and surgical complications were observed.
Results: Neurological recovery and life quality improvement were similar in both groups. Disc height and cervical lordosis (C2-7 Cobb angle) were well restored after operations, but lost in both groups during follow-up. Loss of correction (LOC) in disc height was larger in ZP Group (11.38% vs 5.71%, P < 0.05) at 5-year follow-up. LOC of cervical lordosis in ZP group constantly grew from 11.28% to 48.13% during 5-year follow-up, significantly higher than that in the PC group (from 7.43% to 14.01%) (P < 0.05). The rate of postoperative dysphagia was no statistical difference between the two groups, and symptoms were all disappeared within 1 year. There were 10 levels of adjacent segment degeneration (1 in ZP Group, and 10 in PC Group, P = 0.02). Cage subsidence (11 of 81 levels, 13.58%) and screw migration (2 of 81 levels, 2.47%) were only observed in the ZP Group. The migrated screws in one case were surgically removed. Fusion was achieved in all cases.
Conclusions: In long-term follow-up of 3-level ACDF for CSM, zero-profile spacer has the similar clinical results, but loss of correction of disc height and cervical alignment were significantly higher, compared with anterior plate and cages.
Level Of Evidence: 3.
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http://dx.doi.org/10.1097/BRS.0000000000003312 | DOI Listing |
Turk Neurosurg
July 2025
The Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi People's Hospital, Wuxi Medical Center, Nanjing Medical University.
Aim: Treatment options for cervical spinal cord injury without fracture or dislocation (CSCIWFD) remain varied. Although zero-profile spacers are widely used in degenerative cervical conditions, their long-term efficacy in CSCIWFD is underexplored. This study compared the five-year outcomes of zero-profile spacers and plate-cage constructs in CSCIWFD.
View Article and Find Full Text PDFJt Dis Relat Surg
July 2025
Department of Orthopaedics, Pidu District People's Hospital of Chengdu, Chengdu, China.
Objectives: This study aims to evaluate the hidden blood loss (HBL) and its possible risk factors after anterior cervical discectomy and fusion (ACDF) with zero-profile anchored spacer (ZPAS) in patients with cervical radiculopathy.
Patients And Methods: Between January 2017 and January 2024, a total of 92 patients (44 males, 48 females; mean age: 73.2±10.
Asian Spine J
July 2025
Department of Orthopaedic Surgery, Cleveland Clinic Akron General, Akron, OH, USA.
We conducted a systematic review and network meta-analysis (NMA) to compare the effectiveness of noncontiguous anterior cervical surgical techniques for noncontiguous cervical degenerative disk disease (CDDD) in terms of clinical outcomes. There is a lack of consensus regarding optimal surgical management of noncontiguous CDDD. This NMA compared the clinical effectiveness of various anterior cervical surgical techniques to guide decision-making and improve patient outcomes.
View Article and Find Full Text PDFWorld Neurosurg
October 2024
Department of Orthopedics, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan Province, China. Electronic address:
Objective: To compare the safety, clinical outcomes, and radiological results of anterior cervical discectomy and fusion (ACDF) with zero-profile anchored spacer (ZPAS) versus plate and cage (PC) for 3-level contiguous cervical degenerative disease.
Methods: The study was registered at PROSPERO (CRD42024512706). The Web of Science core collection, PubMed, and Embase were searched up to February 12, 2024.