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Anisotropic magnetic exchange is of great value for the design of high performance molecular nanomagnets. In the present work, enhanced single-chain magnet (SCM) behavior is observed for a Mo -Mn chain that exhibits anisotropic magnetic exchange. Self-assembly of the pentagonal bipyramidal [Mo(CN) ] anion and the Mn unit with a tridentate ligand results in a neutral double zigzag 2,4-ribbon structure which exhibits SCM behavior with a high relaxation barrier of 178(4) K. Open magnetic hysteresis loops are observed below 5.2 K, with a coercive field of 1.5 T at 2 K. Interestingly, this SCM can be considered to be a result of a step-wise process based on our previously reported Mn Mo single-molecule magnets (SMMs).
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http://dx.doi.org/10.1002/anie.202001706 | DOI Listing |
Eur J Pharm Sci
September 2025
Department of Neurology, Massachusetts General Hospital, Boston, MA, 02129, USA; Neuroscience Program, Harvard Medical School, Boston, MA, 02129, USA. Electronic address:
Glioblastoma (GBM) is a highly malignant brain tumor with limited treatment options and poor prognosis. GBM exhibits resistance to conventional therapies, including temozolomide (TMZ), radiotherapy, and immunotherapy, partly due to immunosuppressive mechanisms such as programmed death-ligand 1 (PD-L1) overexpression. To address these challenges, we developed TMZ-loaded nanostructured lipid carriers (NLCs) conjugated with anti-PD-L1 single-chain variable fragments (scFv) for dual chemo-immunotherapy.
View Article and Find Full Text PDFJ Thromb Haemost
September 2025
Blood Research Institute, Versiti, Milwaukee, WI; Department of Pharmacology & Toxicology, Medical College of Wisconsin, Milwaukee, WI; Department of Cell biology, Neurobiology, and Anatomy, Medical College of Wisconsin, Milwaukee, WI. Electronic address:
Background: Human platelets experience structural and functional deterioration during extra-corporeal storage at either room temperature or in the cold, impairing their reactivity and diminishing their hemostatic effectiveness following transfusion. PECAM-1 is an inhibitory receptor on platelets that exerts its inhibitory effects via phosphorylation of tyrosine residues that lie within its cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The purpose of this investigation was to attempt to restore platelet reactivity by impairing the inhibitory activity of PECAM-1.
View Article and Find Full Text PDFVet Res Commun
September 2025
Biopharmaceutical Lab, College of Life Science, Northeast Agricultural University, Harbin, 150030, China.
Background: Canine parvovirus (CPV) poses a severe threat to canine health, necessitating the development of safer and more effective vaccines. While traditional vaccines carry risks of virulence reversion and environmental contamination, subunit vaccines-especially neutralizing epitope vaccines-offer promising alternatives by eliciting targeted immune responses with enhanced safety.
Methods: We employed bacterial display technology to express 11 overlapping CPV VP2 gene fragments on the periplasmic membrane of E.
J Invertebr Pathol
August 2025
State Key Laboratory of Resource Insects, Southwest University, Chongqing 400715, China; Chongqing Key Laboratory of Microsporidia Infection and Control, Southwest University, Chongqing 400715, China. Electronic address:
Pébrine disease, caused by the microsporidium Nosema bombycis, represents a significant challenge to the sericulture industry. To enhance the resistance of silkworm, we developed a transgenic strain (designated N-F12) expressing a single-chain fragment variable antibody F12 (scFvF12), targeting the critical transmembrane protein NbTMP1 of N. bombycis.
View Article and Find Full Text PDFbioRxiv
August 2025
Department of Cancer Immunology, Institute for Cancer Research, Oslo University Hospital, Oslo, Norway.
Induced pluripotent stem cell (iPSC)-derived natural killer (iNK) cells offer a promising platform for off-the-shelf immunotherapy against hematological malignancies. NK cell function is dynamically regulated through education driven by inhibitory receptors, including CD94/NKG2A and killer cell immunoglobulin-like receptors (KIR). However, the acquisition of inhibitory receptors in iNK cells and their role during differentiation and education remains poorly defined.
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