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Marine-derived fungi are an important source of many valuable compounds with original structures and diverse physico-chemical properties. In this work, the metabolomic profile of a strain of , recovered from a snakelocks sea anemone (), was investigated through the parallel application of LC-ESI-HRMS, GC-MS, and NMR. Our strategy allowed the identification of mycophenolic acid, brevianamide A, and several compounds belonging to the thiosilvatins. Among the latter, five products are reported for the first time in this species. The main product of this series, -bis(methylthio)silvatin, was also tested for antiproliferative activity on both cancer and non-tumoral colon cell lines.
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http://dx.doi.org/10.3390/metabo10020055 | DOI Listing |
J Affect Disord
September 2025
Graduate School, Yonsei University College of Medicine, Seoul, Republic of Korea; Department of Preventive Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea. Electronic address:
Background: Intimate partner domestic violence (IPDV) is a global health concern. We explored the association between IPDV and the subsequent onset of hazardous alcohol use among married men and women.
Methods: A total of 13,277 married adults were included in the analysis, with annual repeated measurements from 2009 to 2024, totaling 103,825 observations.
J Gastrointest Surg
September 2025
Department of Surgery, Massachusetts General Hospital, Boston, MA. Electronic address:
Intrahepatic cholangiocarcinoma (iCCA) incidence is increasing globally and is associated with poor prognosis. Surgical resection remains the main curative treatment. However, many patients present with unresectable disease or underlying liver dysfunction, precluding resection.
View Article and Find Full Text PDFFarm Hosp
September 2025
Servicio de Farmacia, Hospital Universitario Ramón y Cajal, IRYCIS, Madrid, España.
Objetives: To design the patient onboarding in a multidisciplinary severe asthma unit, according to the needs identified by patients and professionals in the unit.
Methods: Qualitative study using the human-centred design conducted between November 2022 and February 2023. Patients and professionals from the severe asthma unit and experts in the methodology participated.
Echocardiography
September 2025
Department of Ultrasound Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Background: Identification of significant coronary artery stenosis (CAS) in patients with chronic coronary syndromes (CCS) is crucial for clinical management. Myocardial work (MW) is a new noninvasive method reflecting myocardial metabolism and has been applied in myocardial ischemia. We aimed to explore the value of global MW during vasodilator stress echocardiography in detecting significant CAS.
View Article and Find Full Text PDFJAMA Netw Open
September 2025
Division of Nephrology, Hypertension, and Transplantation, Department of Medicine, University of Florida, Gainesville.
Importance: Predialysis nephrology care is associated with the likelihood of having a mature, usable arteriovenous access for starting hemodialysis (ie, incident vascular access), a key care quality metric for patients with kidney failure. However, the magnitude of this association has not been quantified to date.
Objective: To quantify the attributable association between lack of access to predialysis nephrology care and incident vascular access outcomes among Hispanic patients.