Category Ranking

98%

Total Visits

921

Avg Visit Duration

2 minutes

Citations

20

Article Abstract

Marine-derived fungi are an important source of many valuable compounds with original structures and diverse physico-chemical properties. In this work, the metabolomic profile of a strain of , recovered from a snakelocks sea anemone (), was investigated through the parallel application of LC-ESI-HRMS, GC-MS, and NMR. Our strategy allowed the identification of mycophenolic acid, brevianamide A, and several compounds belonging to the thiosilvatins. Among the latter, five products are reported for the first time in this species. The main product of this series, -bis(methylthio)silvatin, was also tested for antiproliferative activity on both cancer and non-tumoral colon cell lines.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7074196PMC
http://dx.doi.org/10.3390/metabo10020055DOI Listing

Publication Analysis

Top Keywords

identification main
4
main metabolites
4
metabolites marine-derived
4
marine-derived strain
4
strain techniques
4
techniques marine-derived
4
marine-derived fungi
4
fungi source
4
source valuable
4
valuable compounds
4

Similar Publications

Background: Intimate partner domestic violence (IPDV) is a global health concern. We explored the association between IPDV and the subsequent onset of hazardous alcohol use among married men and women.

Methods: A total of 13,277 married adults were included in the analysis, with annual repeated measurements from 2009 to 2024, totaling 103,825 observations.

View Article and Find Full Text PDF

Intrahepatic cholangiocarcinoma (iCCA) incidence is increasing globally and is associated with poor prognosis. Surgical resection remains the main curative treatment. However, many patients present with unresectable disease or underlying liver dysfunction, precluding resection.

View Article and Find Full Text PDF

Objetives: To design the patient onboarding in a multidisciplinary severe asthma unit, according to the needs identified by patients and professionals in the unit.

Methods: Qualitative study using the human-centred design conducted between November 2022 and February 2023. Patients and professionals from the severe asthma unit and experts in the methodology participated.

View Article and Find Full Text PDF

Background: Identification of significant coronary artery stenosis (CAS) in patients with chronic coronary syndromes (CCS) is crucial for clinical management. Myocardial work (MW) is a new noninvasive method reflecting myocardial metabolism and has been applied in myocardial ischemia. We aimed to explore the value of global MW during vasodilator stress echocardiography in detecting significant CAS.

View Article and Find Full Text PDF

Predialysis Nephrology Care Disparities and Incident Vascular Access Among Hispanic Individuals.

JAMA Netw Open

September 2025

Division of Nephrology, Hypertension, and Transplantation, Department of Medicine, University of Florida, Gainesville.

Importance: Predialysis nephrology care is associated with the likelihood of having a mature, usable arteriovenous access for starting hemodialysis (ie, incident vascular access), a key care quality metric for patients with kidney failure. However, the magnitude of this association has not been quantified to date.

Objective: To quantify the attributable association between lack of access to predialysis nephrology care and incident vascular access outcomes among Hispanic patients.

View Article and Find Full Text PDF