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Moving-bed biofilm reactor (MBBR) is a well-established technology for simultaneous nitrification and denitrification (SND). In MBBR, biofilm development and pollutant removal performance are strictly governed by the physico-chemical properties of the carriers. In this study, novel surface-modified carriers with enhanced hydrophilicity (surface contact angle of 60.2 ± 2.3°) and positively-charged surfaces (+11.7 ± 1.1 mV, pH 7.0) had been prepared successfully via polymer blending, and they had also been implemented in SND system for the treatment of real domestic wastewater. Results showed that accelerated startup of SND with more biomass on the carriers was observed in MBBR system filled with surface-modified carriers. At low DO level (0.6-0.8 mg L) and low C/N ratio (≤5), highly efficient organics removal and SND performance could be achieved with COD removal, TN removal and SND efficiencies of 79.3-85.7%, 62.0-75.9% and 58.5-71.8%, respectively. The efficient performance of SND in MBBR system filled with surface-modified carriers was mainly attributed to the coexistence of enriched mixtrophic nitrifiers and denitrifiers like autotrophic nitrifers (Nitrosomonas, Nitrospira, Nitrobacter), heterotrophic nitrifers (Rudaea), aerobicdenitrifiers (Dokdonella, Terrimonas), anoxic denitrifiers (Gemmobacter, Ottowia, Methyloversatilis, Thermomonas) and NO producer (Mesorhizobium).
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http://dx.doi.org/10.1016/j.chemosphere.2020.125831 | DOI Listing |
Ultrason Sonochem
August 2025
National Key Laboratory of Agricultural Microbiology, College of Chemistry, College of Life Science and Technology, Huazhong Agricultural University, Wuhan 430070, China.
The rapid spread of drug-resistant bacterial infections has become a major global health challenge, particularly in the treatment of deep organ abscesses, which often lead to severe and life-threatening infections. Traditional light-responsive and microenvironment-responsive nanoparticle drug delivery systems (DDSs) have limitations in treating deep abscesses. In contrast, ultrasound (US)-driven sonodynamic therapy (SDT), with its non-invasive, targeted radiation and excellent tissue penetration capabilities, offers great potential for eradicating deep bacterial infections.
View Article and Find Full Text PDFAdv Mater
August 2025
Instituto de Nanociencia y Materiales de Aragón (INMA), CSIC-Universidad de Zaragoza, Zaragoza, 50009, Spain.
Bacteria exhibit adaptive phenotypic traits that confer resistance to host defenses and antimicrobial therapies. In response to the global threat of antimicrobial resistance, bacteria-responsive nanostructured drug delivery systems have emerged as a promising alternative to conventional broad-spectrum antimicrobials. These systems release therapeutics selectively in response to bacterial presence or to their secreted enzymes, toxins, antigens, or extracellular biomarkers, enabling precise activation at infection sites while minimizing off-target effects.
View Article and Find Full Text PDFAngew Chem Int Ed Engl
August 2025
Department of Energy Engineering/KENTECH Institute for Environmental and Climate Technology, Korea Institute of Energy Technology (KENTECH), Naju, Jeollanam-do, 58330, Republic of Korea.
Surface and interface engineering is essential for constructing efficient and stable photoelectrodes for photoelectrochemical (PEC) solar fuel production. Despite the recent advances in photoelectrode optimization for the practical application, the corresponding interfacial reaction mechanism has not been elucidated owing to a lack of suitable measurements at the semiconductor-electrolyte interface (SEI). Herein, the key factor for an interfacial reaction in a model system (WO photoanode coated with amorphous TiO overlayers) is elucidated using operando spectroelectrochemistry.
View Article and Find Full Text PDFJ Pharm Sci
August 2025
Department of Industrial and Physical Pharmacy, Purdue University, West Lafayette, IN 47907, USA.
This study investigates the use of an octenylsuccinate-modified dendrimer-like biopolymer (OS-DLB) as a carrier matrix in the formulation of biodendrimeric solid dispersions (BDSDs) using hot melt extrusion (HME). Ibuprofen (IBU) and griseofulvin (GSF) were selected as model compounds due to their poor aqueous solubility - one limited by its hydrophobicity and the other by its strong crystal lattice, respectively. This study demonstrates that the BDSD formulation can significantly enhance the dissolution rates of the model compounds through a parallel liquid phase equilibrium, while retaining their predominantly crystalline state.
View Article and Find Full Text PDFInt J Biol Macromol
September 2025
Department of Pharmaceutics, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal 576104, Karnataka, India. Electronic address:
This study details the development and evaluation of a zinc-based MOF (MOF-74) for targeted cancer therapy. Doxorubicin (DOX) was selected as the active pharmaceutical ingredient because of its well-established efficacy against cancer. Preformulation studies were conducted to identify, and characterise DOX, and to establish quantitative methods for its estimation.
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