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Objective: Patients with coronary artery disease (CAD) are susceptible to the negative emotion and its adverse influence on the disease prognosis. It is of great necessity to have a simple measurement to timely assess negative emotions in patients with CAD. The Negative Emotions due to Chronic Illness Screening Test (NECIS) is a newly developed tool to measure negative emotions. However, the construct validity has not been established yet. Therefore, the purpose of this study was to test the construct validity of the NECIS in individuals with CAD in mainland China.
Methods: The tool was administered in a convenience sample of 376 patients with CAD hospitalized in three general hospitals in Wuhan City, China. Construct validity was evaluated through factorial validity, convergent validity and discriminant validity. Additionally, the assumed relationship between negative emotions with other associated variables (perceived control and perceived social support) was tested to provide additional evidence of the construct validity of the NECIS.
Results: Exploratory factor analysis and confirmatory factor analysis established and confirmed a two-factorial structure of the NECIS. Convergent validity and discriminant validity of the NECIS were proven to be adequate. Two hypotheses regarding the relationship between negative emotions and associated variables (perceived control and perceived social support) were confirmed, which supported the satisfactory construct validity of the NECIS.
Conclusion: The NECIS had sound construct validity when applied to patients with CAD in mainland China. This study added new knowledge regarding the construct validity of the NECIS, which supported its psychometric properties for future use.
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http://dx.doi.org/10.2147/PPA.S232935 | DOI Listing |
Stem Cell Rev Rep
September 2025
Department of Medical Genetics and Prenatal Diagnostics, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
The emergence of organoid models has significantly bridged the gap between traditional cell cultures/animal models and authentic human disease states, particularly for genetic disorders, where their inherent genetic fidelity enables more biologically relevant research directions and enhances translational validity. This review systematically analyzes established organoid models of genetic diseases across organs (e.g.
View Article and Find Full Text PDFJ Assist Reprod Genet
September 2025
Department of Gynecology, Pingxiang Maternal and Child Health Hospital, PingXiang, Jiangxi, China.
Objective: This study aimed to identify key predictors of uterine fibroid (UF) recurrence following laparoscopic myomectomy (LM) in reproductive-age women and to construct a predictive nomogram to support individualized clinical decision-making.
Methods: This retrospective cohort study included 459 women who underwent LM. Recurrence of UFs and risk of recurrence were analyzed.
Ren Fail
December 2025
Department of Critical Care Medicine, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, China.
This study aimed to develop a predictive model and construct a graded nomogram to estimate the risk of severe acute kidney injury (AKI) in patients without preexisting kidney dysfunction undergoing liver transplantation (LT). Patients undergoing LT between January 2022 and June 2023 were prospectively screened. Severe AKI was defined as Kidney Disease: Improving Global Outcomes stage 3.
View Article and Find Full Text PDFProg Neuropsychopharmacol Biol Psychiatry
September 2025
School of Mathematics and Statistics, Guangdong University of Foreign Studies, Guangzhou, PR China. Electronic address:
Background: Sexual dimorphism in human brain has garnered significant attention in neuroscience research. Although multiple investigations have examined sexual dimorphism in gray matter (GM) functional connectivity (FC), the research of white matter (WM) FC remains relatively limited.
Methods: Utilizing resting-state fMRI data from 569 healthy young adults, we investigated sexual dimorphism in the WM functional connectome.
Biochim Biophys Acta Gen Subj
September 2025
Department of Biotechnology, Faculty of Applied Science, King Mongkut University of Technology North Bangkok, Bangkok 10800, Thailand; Food and Agro-Industrial Research Center, King Mongkut's University of Technology North Bangkok, Bangkok 10800, Thailand,. Electronic address:
In modern drug discovery, there is a pressing need for rapid, cost-effective, and accessible methods to evaluate the biological activities of newly synthesized compounds. Traditional kinase assay platforms are often labor-intensive, time-consuming, and require specialized equipment or expertise. To address these limitations, we developed and validated a convenient in vitro kinase assay based on a recombinant biosensor, Picchu-B, constructed using a bacterial expression system.
View Article and Find Full Text PDF