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infections continue to be an important cause of morbidity and mortality in low-and middle-income countries. Differentiating from viridans group streptococci is essential to ensure appropriate antibiotic therapy. Conventional microbial identification tests can often misidentify the two groups. We used a common pneumococcal urinary antigen test to identify that were misidentified by the VITEK 2. The performance of the test was similar to the pneumococcal latex agglutination test.
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http://dx.doi.org/10.1177/0049475519889717 | DOI Listing |
PLoS One
August 2025
Department of Internal Medicine, Division of Pulmonology and Critical Care Medicine, Chonnam National University Hospital, Gwangju, South Korea.
Background: Bacterial co-infection has been associated with adverse outcomes in patients with COVID-19. Streptococcus pneumoniae is a common cause of community-acquired pneumonia and may contribute to poor clinical outcomes when co-detected in COVID-19 patients. This study aimed to investigate the clinical significance of pneumococcal positivity in hospitalized patients with COVID-19.
View Article and Find Full Text PDFBMC Infect Dis
August 2025
Section of Infectious Diseases, Department of Pediatrics, Children's Hospital Colorado, University of Colorado, Aurora, CO, USA.
Background: Urinary antigen detection (UAD) assays can address diagnostic challenges with culture-based identification of S. pneumoniae. We aimed to evaluate the utility of Pfizer's UAD1 and UAD2 assays for pneumococcal serotype surveillance in children with community acquired pneumonia (CAP) or upper respiratory tract infections (URI).
View Article and Find Full Text PDFJAMA Netw Open
August 2025
Vanderbilt University Medical Center, Nashville, Tennessee.
Importance: Although the use of pneumococcal conjugate vaccines (PCV) has reduced the overall burden of pneumococcal disease, recent measurements of pneumococcal pneumonia incidence are lacking.
Objective: To prospectively quantify the burden of pneumococcal pneumonia and to assess the potential impact of the recently approved adult-specific 21-valent pneumococcal conjugate vaccine (V116).
Design, Settings, And Participants: This cross-sectional study for prospective active surveillance included adults residing in defined catchment areas in Tennessee and Georgia hospitalized with clinical and radiographical evidence of community-acquired pneumonia (CAP) at 3 hospitals between 2018 and 2022.
Eur J Clin Microbiol Infect Dis
July 2025
Center of Research and Disruption of Infectious Diseases, Department of Infectious Diseases, Copenhagen University Hospital - Amager and Hvidovre, Hvidovre, Denmark.
To establish a microbiological etiology in severe community-acquired pneumonia (CAP), most guidelines recommend adding urinary antigen tests (UAT) to respiratory sampling. However, their usage and impact remain unclear. We examined the clinical impact of UAT in hospitalized CAP patients.
View Article and Find Full Text PDFCureus
May 2025
Medicine, Mu'tah University, Mu'tah, JOR.
Tension empyema is a rare, life-threatening condition characterized by infected pleural effusion leading to significant respiratory distress, mediastinal shift, and hemodynamic instability. We present a unique case of a 55-year-old male with a history of alcohol use disorder who presented with productive cough, hemoptysis, shortness of breath, and left-sided back pain persisting for over one month. Imaging demonstrated a unilocular fluid collection in the left upper anterior pleural space and a large loculated left-sided hydropneumothorax causing mediastinal shift, raising concern for tension empyema.
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