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Article Abstract
In this study, we examined whether smoking and drinking affect sperm quality and the DNA methylation of the repetitive element , , , , and in sperm. Semen samples were obtained from 143 male residents in a minority-inhabited district of Guizhou province in southwest China. Quantitative DNA methylation analysis of the samples was performed using MassARRAY EpiTYPER assays. Sperm motility was significantly lower in both the nicotine-exposed (P = 0.0064) and the nicotine- and alcohol-exposed (P = 0.0008) groups. Follicle-stimulating hormone (FSH) levels were higher in the nicotine-exposed group (P = 0.0026). The repetitive element was hypermethylated in the three exposed groups, while was hypomethylated in the alcohol and both the alcohol and nicotine exposure groups. Our results also show that alcohol and nicotine exposure altered sperm cell quality, which may be related to the methylation levels of and . In addition, , , and the repetitive element methylation was significantly associated with the concentration of sperm as well as FSH and luteinizing hormone levels.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6813923 | PMC |
| http://dx.doi.org/10.3389/fgene.2019.01001 | DOI Listing |
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