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http://dx.doi.org/10.3967/bes2019.063 | DOI Listing |
Front Biosci (Landmark Ed)
August 2025
Department of Thoracic Surgery, The Seventh Affiliated Hospital, Sun Yat-Sen University, 518107 Shenzhen, Guangdong, China.
Background: Adenocarcinoma of Lung (LUAD) remains a leading cause of cancer-related deaths across the globe, and patients harboring epidermal growth factor receptor (EGFR) mutations frequently develop resistance to targeted therapies. While aurora kinase A (AURKA) has been implicated in tumorigenesis, its involvement in regulating ferroptosis via the kelch-like ECH-associated protein 1 (KEAP1)/NF-E2-related factor 2 (NRF2)/heme oxygenase 1 (HO‑1) signaling axis in EGFR-mutant LUAD remains poorly understood.
Methods: We analyzed RNA-seq and clinical data from 594 LUAD samples from The Cancer Genome Atlas (TCGA) to explore associations between AURKA expression, EGFR mutation status, and immune cell infiltration.
Neurochem Res
September 2025
Department of Neurosurgery, The Second Hospital of Hebei Medical University, Shijiazhuang, 050000, Hebei, China.
Intracerebral hemorrhage (ICH) is a common yet severe cerebrovascular disorder associated with high morbidity, disability, and mortality rates. Kaempferol (Kae), a natural flavonoid with potent antioxidant and anti-inflammatory properties, has shown promise in neuroprotection; however, its therapeutic potential in promoting neurological recovery after ICH remains unclear. In this study, we investigated the neuroprotective effects of Kae in ICH and explored its underlying mechanisms using in vitro and in vivo models.
View Article and Find Full Text PDFCNS Neurosci Ther
September 2025
School of Public Health, Guangxi Medical University, Nanning, Guangxi, China.
Background: Lead (Pb) exposure is recognized for its contribution to the development of neurodegenerative diseases. However, the precise mechanisms underlying Pb-induced neurological dysfunction remain elusive. This study aimed to investigate the role of oxidative stress and the autophagy-related P62/kelch like ECH-associated protein 1 (Keap1)/Nuclear factor erythroid 2-related factor 2 (Nrf2) pathway in neuronal impairment caused by Pb.
View Article and Find Full Text PDFJ Neurochem
September 2025
Toxicology Unit, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
Polar metabolic profiling, as well as bioenergetic assays, were used to characterize microglial responses to lipopolysaccharide, which induces a pro-inflammatory state, and interleukin-4, which is associated with an anti-inflammatory phenotype. BV2 microglial cells and primary microglia were used for these investigations. Results revealed that lipopolysaccharide-treated microglia exhibited an increased aerobic glycolytic activity measured by extracellular flux analysis, accompanied by increased levels of endogenous itaconate, a metabolite produced by the IRG1 enzyme.
View Article and Find Full Text PDFEur J Med Res
September 2025
Department of Plastic Surgery, Fancheng District, Xiangyang No.1 People's Hospital, Hubei University of Medicine, No.15, Jiefang Road, Xiangyang, 441000, Hubei, China.
Objectives: The study aimed to investigate the relationship between serum nuclear factor erythroid 2-related factor 2 (NRF2) levels and the severity of diabetic foot ulcers (DFU) and to identify potential risk factors in severe DFU patients. Understanding this relationship could offer insights into mechanisms underlying DFU progression and inform diagnostic and therapeutic strategies.
Methods: This prospective observational study included 195 DFU patients from January 2023 to May 2024, categorized into mild and severe groups using the Wagner classification system.