Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Tephrosia purpurea (L.) Pers., commonly known as "sarpunkha" and "wild indigo", is being used in traditional systems of medicine to treat liver disorders, spleen and kidney. In the present study, a validated High Performance Thin Layer Chromatography (HPTLC) method was established for the estimation of lupeol, β-sitosterol and rotenone in various extracts of T. purpurea with the aim to see the effect of seasons on the quantity of aforesaid phytoconstituents. The plant material was collected in summer (April), rainy (August) and winter (December) during 2013-2014 from Lucknow, India. The method was validated in terms of precision, repeatability, specificity, sensitivity linearity and robustness. The method permits reliable quantification and showed good resolution on silica gel with toluene-ethyl acetate-formic acid (9:1:1 v/v/v) as mobile phase, and characteristic bands of β-sitosterol, rotenone and lupeol were observed at Rf 0.38, 0.45 and 0.52, respectively. The content of aforesaid phytoconstituents varies from season to season and extract to extract. Our finding indicated that winter season (December) may not be appropriate for collection of T. purpurea for the preparation of therapeutic formulations because of the high content of rotenone, a known insecticide that is responsible for Parkinson's disease and associated with heart failure, fatty liver and liver necrosis.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1093/chromsci/bmz041 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Functional characterization of odorant binding proteins in Pharsalia antennata provides insights into diverse binding properties and the importance of C-terminal residues.
Pestic Biochem Physiol
November 2025
Key Laboratory of Forest Disaster Warning and Control of Yunnan Province, Southwest Forestry University, Kunming 650224, China. Electronic address:
The cerambycid beetles are important components in the terrestrial ecosystem as they play a dual role in both degrading dying trees and killing healthy plants. The factors including human activity, habitat contraction, climate changes and pesticide use have been shaping the adaptation of beetles to host plants and the environment. As suggested in research on the functions of beetles' olfactory proteins, odorant binding proteins (OBPs) have been found to be involved in insecticide resistance other than chemoreception.
View Article and Find Full Text PDFEndoplasmic reticulum stress modulation by Alpha-Pinene in a rotenone-induced rat model of Parkinson's disease.
Eur J Pharmacol
September 2025
Faculty of Medicine, Department of Histology and Embryology, İzmir Katip Çelebi University, İzmir, Turkiye.
Age is the most significant risk factor for Parkinson's disease, a common and progressive neurodegenerative disorder; however, exposure to toxic substances is also strongly implicated. Rotenone, an organic pesticide, induces neuropathological features of Parkinson's disease, and is widely used to create rodent models of the condition. Although the molecular mechanisms involved in the onset and progression of the disease are still unknown, neurodegenerative diseases due to protein accumulation in certain areas of the brain, have been associated with endoplasmic reticulum stress.
View Article and Find Full Text PDFJMJ720 encodes an H3K9me2 demethylase that regulates grain size in rice.
Plant J
September 2025
Rice Research Institute of Shenyang Agricultural University, Shenyang, 110 866, China.
Grain size is a crucial determinant of rice yield, yet the molecular mechanisms controlling this trait remain only partially understood. Here, we identified the JMJ720 locus as a key regulator of grain size through map-based cloning. The jmj720 mutant was found to exhibit significantly larger grains when compared to the wild type (WT).
View Article and Find Full Text PDFPLEKHF1 Induces Mitochondrial Dysfunction to Inhibit Osteosarcoma Growth and Metastasis.
IUBMB Life
September 2025
Department of Orthopaedics, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Osteosarcoma (OS) is an uncommon malignancy with stagnant survival rates over the past four decades and early-stage metastasis, predominantly affecting children and adolescents. This study identified significant metabolic differences between metastatic and non-metastatic OS samples through bioinformatics analysis, highlighting key processes such as cell proliferation, mitochondrial assembly, and changes in mitochondrial membrane permeability. Among differentially expressed genes, Pleckstrin Homology And FYVE Domain Containing 1 (PLEKHF1) was the most significantly downregulated in metastatic OS samples.
View Article and Find Full Text PDFA multifunctional terbium-based metal-organic framework for ultrasensitive detection of ethyl maltol, gallic acid, and rotenone in complex food matrices.
Food Chem
August 2025
School of Chemistry and Biological Engineering, University of Science and Technology Beijing, Beijing 100083, China. Electronic address:
The detection of Ethyl maltol (EM), Gallic acid (GA), and Rotenone in food is critical for preventing foodborne diseases. This study developed a new terbium-based metal-organic framework (Tb-MOF) for ultrasensitive multi-target detection in complex food matrices leveraging competitive absorption mechanism. It is the first MOF-based sensor detecting EM with LOD of 0.
View Article and Find Full Text PDF