The use of magnetic starch as a support for an ionic liquid-β-cyclodextrin based catalyst for the synthesis of imidazothiadiazolamine derivatives.

In this paper, a novel catalyst is introduced based on the introduction of an ionic liquid onto the β-cyclodextrin. The ionic liquid-β-cyclodextrin was anchored to magnetic starch (denoted βCD-IL@M-Starch) and fully characterized by several methods including TEM, TGA, VSM and FT-IR. The catalyst was used for the synthesis of imidazo[2,1-b][1,3,4]thiadiazol-5-amine and imidazo[1,2-a]pyridin-3-amine derivatives. βCD-IL@M-Starch catalyst showed very good activity in the synthesis of diphenylimidazo[2,1-b][1,3,4]thiadiazol-5-amine derivatives from the corresponding benzaldehyde, semicarbazide, benzaldehydes and isocyanides. The products were obtained in a mild reaction conditions in good isolated yields in the presence of βCD-IL@M-Starch as catalyst. The catalyst showed to be magnetically reusable, and gave very good results in 10 sequential reactions.