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Objective: To develop and evaluate the Collective Efficacy of Networks (CENS) questionnaire to measure perceived collective efficacy within personal social networks.
Methods: A mixed methods approach was used, guided by theory and with extensive input from adults with long-term conditions who completed the initial questionnaire (n = 78) with test-retest assessed at 2 weeks (n = 68). A second sample (n = 85) completed a postal questionnaire including CENS, theoretically linked constructs (self-efficacy, social support) and health outcomes (loneliness, mental and physical health).
Results: Principal components analysis demonstrated a two-factor structure with 12-items selected to represent Network responsiveness (8 items, Cronbach's alpha = 0.896) and Access to collective efficacy (4 items, Cronbach's alpha = .773). Good test-retest reliability was established for both subscales (r = .793-.853). Network responsiveness was associated with self-efficacy (r = 342, p = . < 001) and social support (r = .407, p < .001) and predicted reduced loneliness. Access to collective efficacy significantly predicted better mental health; the predictive validity of the subscales improved when combined with self-efficacy.
Conclusion: The CENS is an acceptable and psychometrically robust measure of collective efficacy in personal social networks.
Practice Implications: Measuring collective efficacy with self-efficacy will provide useful information for researchers and policymakers interested in capacity for self-management and social determinants of behaviour change.
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http://dx.doi.org/10.1016/j.pec.2019.02.026 | DOI Listing |
Stroke
September 2025
Department of Neurology, Yale School of Medicine, New Haven, CT (L.H.S.).
Preclinical stroke research faces a critical translational gap, with animal studies failing to reliably predict clinical efficacy. To address this, the field is moving toward rigorous, multicenter preclinical randomized controlled trials (mpRCTs) that mimic phase 3 clinical trials in several key components. This collective statement, derived from experts involved in mpRCTs, outlines considerations for designing and executing such trials.
View Article and Find Full Text PDFCurr Opin Urol
September 2025
European Association of Urology Section of Endourology (ESEUT), Arnhem, The Netherlands.
Purpose Of Review: This opinion article from the EAU Endourology Section critically summarizes the existing evidence on flexible and navigable suction ureteral access sheaths (FANS) to determine if they represent a paradigm shift in managing kidney and ureteral stones with flexible ureteroscopy (FURS). This scoping review aims to synthesize recent findings on FANS efficacy, safety, and potential to overcome limitations of conventional ureteral access sheath (C-UAS) and other modalities.
Recent Findings: Current evidence demonstrates FANS significantly outperforms C-UAS.
Front Biosci (Landmark Ed)
August 2025
Laboratory of Molecular Immunology, Federal State Budgetary Scientific Institution Research Institute of Fundamental and Clinical Immunology, 630099 Novosibirsk, Russia.
Background: Disialoganglioside (GD2) is a tumor-associated antigen that is highly expressed in various neuroectodermal cancers, including melanoma. While chimeric antigen receptor (CAR) T-cell immunotherapy has demonstrated remarkable success in treating hematologic neoplasms, the identification of suitable targets remains a major obstacle in translating this approach to solid tumors.
Methods: Peripheral blood T lymphocytes from six healthy donors were used to generate GD2-specific CAR T cells via retroviral transduction.
PLoS Negl Trop Dis
September 2025
Environmental Health Group, Faculty of Infectious Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom.
Background: Chikungunya virus (CHIKV) is an arbovirus with a significant global public health burden. Delineating the specific contributions of individual behaviour, household, natural and built environment to CHIKV transmission is important for reducing risk in urban informal settlements but challenging due to their heterogeneous environments. The aim of this study was to quantify variation in CHIKV seroprevalence between and within four urban communities in a large Brazilian city, and identify the respective contributions of individual, household, and environmental factors for seropositivity.
View Article and Find Full Text PDFHum Vaccin Immunother
December 2025
Department of Planned Immunization, Chaoyang District Centre for Disease Control and Prevention, Beijing, China.
Mumps is a vaccine-preventable disease. Following Beijing's implementation of a three-dose MMR vaccination strategy, incidence rates declined significantly. However, the current 21-d quarantine period lacks evidence-based support, resulting in low compliance and conflicts between healthcare providers and patients.
View Article and Find Full Text PDF