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Guided primarily by life history theory, this study was designed to identify how and why early exposure to caregiver intimate relationship instability uniquely predicts children's externalizing symptoms in the context of other dimensions of unpredictability characterized by residential and parental job transitions. Participants included 243 preschool children ( = 4.60 years) and their mothers who participated in 3 annual measurement occasions (i.e., preschool, kindergarten, first grade). Supporting the first link in the hypothesized mediational chain, the results of structural equation modeling analyses indicated that caregiver intimate relationship instability uniquely predicted a pattern of response processes over a 1-year period characterized by negative family representations, dominant interpersonal strategies for regulating resources, and diminished task persistence. Latent difference score analyses of each of these response processes over the 1-year period, in turn, uniquely predicted a multiinformant (i.e., mother, teacher, experimenter) assessment of children's externalizing symptoms over a 2-year period. Mediational findings were robust after accounting for the negligible roles of residential and occupational changes as simultaneous predictors. Results are interpreted in the context of how they inform and support life history theory as well as other conceptual (e.g., attachment and emotional security theory) models. (PsycINFO Database Record (c) 2019 APA, all rights reserved).
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http://dx.doi.org/10.1037/dev0000717 | DOI Listing |
Crit Rev Immunol
January 2025
State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, Chengdu, Sichuan, China.
Stemming from human immune organs, tonsil-derived mesenchymal stem cells (TMSCs) hold unique strengths in differentiation potential and immune regulatory functions. These characteristics make them valuable for therapeutic applications, particularly in regenerative medicine and autoimmune disease treatment, as they can modulate immune responses and promote tissue repair. Their ability to interact with various cell types and secrete a range of bioactive molecules further enhances their role in orchestrating healing processes, making them a promising avenue for innovative therapies aimed at restoring balance in the immune system and facilitating recovery from injury or disease.
View Article and Find Full Text PDFNeural Netw
September 2025
School of Electronic Science and Engineering, Nanjing University, China. Electronic address:
The Segment Anything Model (SAM) is a cornerstone of image segmentation, demonstrating exceptional performance across various applications, particularly in autonomous driving and medical imaging, where precise segmentation is crucial. However, SAM is vulnerable to adversarial attacks that can significantly impair its functionality through minor input perturbations. Traditional techniques, such as FGSM and PGD, are often ineffective in segmentation tasks due to their reliance on global perturbations that overlook spatial nuances.
View Article and Find Full Text PDFJMIR Hum Factors
September 2025
College of Biomedical Engineering & Instrument Science, Zhejiang University, Hangzhou, China.
Background: The rapid advancement of next-generation sequencing has significantly expanded the landscape of precision medicine. However, health care professionals face increasing challenges in keeping pace with the growing body of oncological knowledge and integrating it effectively into clinical workflows. Precision oncology decision support (PODS) tools aim to assist clinicians in navigating this complexity, yet their current functionalities only partially address clinical needs.
View Article and Find Full Text PDFAge Ageing
August 2025
Department of Social Determinants of Health, Division of Healthier Populations, World Health Organization, Geneva, Switzerland.
The Abuse of Older People - Intervention Accelerator (AOP-IA) project aims to accelerate the development of effective interventions to prevent and reduce AOP aged 60 and older within the framework of the United Nations Decade of Healthy Ageing (2021-2030). The AOP-IA was launched in response to the global need for interventions with proven effectiveness, as few existing approaches have been rigorously evaluated. This paper focuses on the first two phases of the AOP-IA project, which involved conducting a systematic search, screening and evaluation process to identify candidate interventions ready to be rigorously evaluated in future stages of the project, as well as establishing a network of intervention developers.
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