Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Patients with early-stage chronic kidney disease (CKD) are susceptible to changes in metabolic processes. Partial loss of kidney function leads to homoeostatic disturbances in bone and fatty tissue. The aim of this study was to investigate the association between plasma concentrations of Klotho protein, FGF23, leptin, adiponectin, osteocalcin, and bone mineral density (BMD) in patients with CKD in the pre-dialysis period. The study involved 52 patients with CKD and 23 patients with no kidney disease. In both groups, BMD, body mass index and serum or plasma concentrations of lipids, glucose, creatinine, calcium, phosphorus, parathormone, leptin, adiponectin, osteocalcin, Klotho, and FGF23 were measured. The group with CKD had statistically significant higher concentrations of leptin (p<0.001), parathormone (p<0.001), and osteocalcin (p<0.001) in comparison with the control group. Patients with CKD also had statistically significant lower BMD in the femoral neck in comparison with the control group. Osteocalcin correlated negatively with BMD. The results of our study suggest that elevated osteocalcin is the most sensitive marker of decreased bone mass in patients with CKD. Osteocalcin correlated negatively with BMD and GFR. The loss of bone mass in CKD patients was greatest in the femoral neck.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1055/a-0752-4615 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Multifunctional Roles and Therapeutic Prospects of C1q/TNF-Related Protein 3 (CTRP3) in Human Diseases.
Curr Med Sci
September 2025
Department of Cardiovascular Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
Adipokines, including C1q/tumor necrosis factor (TNF)-related proteins (CTRPs), adiponectin, TNF-α, and leptin, are crucial bioactive molecules that are secreted by adipose tissue and circulate in the bloodstream. To date, 15 members of the CTRP family, which are collectively classified as part of the C1q/TNF superfamily, have been identified. Among these, CTRP3 stands out as a unique adipokine because of its distinct structural and functional properties.
View Article and Find Full Text PDFThe protective effect of Saudi Arabian bee honey against excessive weight gain and obesity-related parameters in rats fed a high-fat diet.
Front Nutr
August 2025
Department of Food Sciences and Nutrition, College of Food and Agricultural Sciences, King Saud University, Riyadh, Saudi Arabia.
Introduction: This study aimed to investigate the anti-obesity, hepatic protective, and metabolic effects of Sidr and Talh honey, two Saudi honey, in rats fed a high-fat diet (HFD) and examined some possible mechanisms of their action.
Methods: Adult rats were divided into eight groups ( = 8 each) and were administered HFD for 12 weeks, with or without oral doses of Sidr or Talh honey at 500, 700, and 1,000 mg/kg.
Results And Discussion: Talh honey significantly reduced body weight, fat mass, and adiposity markers, including mesenteric, subcutaneous, and epididymal fat, compared to the HFD group.
Assessment of adipokine and inflammation biomarkers with cancer risk among Chinese men: A prospective cohort study.
Cancer Epidemiol Biomarkers Prev
September 2025
Vanderbilt University Medical Center, Nashville, TN, United States.
Background: Obesity and chronic inflammation are associated with cancer risk. We investigated the association between adipokines, inflammation markers, and cancer risk among Chinese men.
Methods: Using pre-diagnosis fasting plasma samples from 4,051 (6.
Differential NADP-Dependent Isocitrate Dehydrogenases Expression in Metabolically Healthy Obesity vs Metabolic Syndrome: A Probable Predictive Biomarker for Metabolic Deterioration.
J Appl Lab Med
September 2025
Faculty of Science, Tanta University, Tanta, Egypt.
Background: Nicotinamide adenine dinucleotide phosphate (NADP)-dependent isocitrate dehydrogenases, isocitrate dehydrogenase enzyme (IDH)1 and IDH2, are crucial to normal glucose and lipid metabolism and to oxidative species handling. This study aimed to assess the probability of utilizing NADP-dependent isocitrate dehydrogenases deficiency as a biomarker of the progression of metabolically healthy obesity (MHO) to metabolic syndrome (MetS).
Methods: The study enrolled 120 participants.
Effects of different exercise prescription parameters on metabolic and inflammatory biomarkers in cancer patients: a systematic review, meta-analysis, and meta-regression.
Front Immunol
September 2025
Department of Physical Education, College of Education, Korea University, Seoul, Republic of Korea.
Objective: This study aimed to systematically evaluate the effects of exercise interventions on metabolic and inflammatory biomarkers in cancer patients, and to identify potential dose-response relationships and modulatory mechanisms using Robust Variance Estimation (RVE) and MetaForest models.
Methods: A systematic search of five databases was conducted from inception to March 6, 2025, based on the PICOS framework. Randomized controlled trials involving exercise interventions of ≥4 weeks in adults (≥18 years) with cancer were included.