Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Background: This study was performed to identify disease-related genes and analyze prognostic values in nonsmoking females with non-small cell lung carcinoma (NSCLC).
Materials And Methods: Gene expression profile GSE19804 was downloaded from the Gene Expression Omnibus (GEO) database and analyzed by using GEO2R. Gene Ontology and Kyoto Encyclopedia of Genes and Genomes were used for the functional and pathway enrichment analysis. Then, the Search Tool for the Retrieval of Interacting Genes, Cytoscape, and Molecular Complex Detection were used to construct the protein-protein interaction (PPI) network and identify hub genes. Finally, the Kaplan-Meier plotter online tool was used for the overall survival analysis of hub genes.
Results: A cohort of 699 differentially expressed genes was screened, and they were mainly enriched in the terms of ECM-receptor interaction, focal adhesion, and cell adhesion molecules. A PPI network was constructed, and 15 hub genes were identified base on the subset of PPI network. Then, two significant modules were detected and several genes were found to be associated with the cell cycle pathway. Finally, nine hub genes' (UBE2C, DLGAP5, TPX2, CCNB2, BIRC5, KIF20A, TOP2A, GNG11, and ANXA1) expressions were found to be associated with the prognosis of the patients.
Conclusion: Overall, we propose that the cell cycle pathway may play an important role in nonsmoking females with NSCLC and the nine hub genes may be further explored as potential targets for NSCLC diagnosis and treatment.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6183654 | PMC |
| http://dx.doi.org/10.2147/CMAR.S174409 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Awareness and uptake of herpes zoster vaccine among patients with diabetes mellitus in the Aseer Region, Saudi Arabia: A cross-sectional study.
Medicine (Baltimore)
September 2025
Family and Community Medicine, College of Medicine, King Khalid University, Abha, Saudi Arabia.
Herpes zoster (HZ) is a reactivation of the varicella-zoster virus. It is a common infection, especially among patients with diabetes mellitus (DM). This study aimed to assess the awareness and uptake of the HZ vaccine, as well as their determinants, among patients with diabetes DM in the Aseer Region, Saudi Arabia.
View Article and Find Full Text PDFAssociation between vitamin K intake and periodontitis in American elderly population: a cross-sectional analysis of NHANES data.
Clin Oral Investig
September 2025
Background: An increasing amount of data has been acquired on the close relationship between Vitamin K intake and the progression of periodontitis. The purpose of this study was to estimate whether Vitamin K intake is associated with periodontitis among older adults in America using information from the National Health and Nutrition Examination Survey (NHANES) database.
Methods: A cross-sectional analysis of data on periodontal indices and vitamin K intake among American adults aged 60 years and older in the 2009-2014 NHANES database was extracted.
Assessment of the Relation Between Diabetes Mellitus and Current Smokers Across Varying Demographics and Socioeconomic Characteristics: A Cross-Sectional Study.
Cureus
August 2025
Pharmacy Practice, Balaji Institute of Pharmaceutical Sciences, Warangal, IND.
Introduction: Smoking induces oxidative stress and inflammation, which can impair insulin function and increase the risk of developing diabetes. Understanding this modifiable risk factor across diverse demographic and socioeconomic groups is essential for targeted public health interventions.
Aims: To assess the relationship between current smoking and self-reported diabetes and to analyze how this association varies across demographics and socioeconomic characteristics.
Association between the Chinese Dietary Inflammatory Index and risk of gastric cancer: a case-control study in Southeastern China.
Front Nutr
August 2025
Fujian Provincial Key Laboratory of Environment Factors and Cancer, Department of Epidemiology and Health Statistics, School of Public Health, Fujian Medical University, Fuzhou, China.
Objective: This study aimed to investigate the association between the Chinese Dietary Inflammatory Index (CHINA-DII) and the risk of gastric cancer (GC) among adults in Fujian Province of China.
Methods: A 1:1 matched case-control study was conducted between July 2023 and November 2024. A total of 336 newly diagnosed GC cases were recruited from the Union Hospital, and 336 sex-matched healthy controls were enrolled from communities in Fujian Province.
Association Between Smoking and Stroke: A Retrospective Study Using the 2022 Behavioral Risk Factor Surveillance System (BRFSS) Data.
Cureus
July 2025
Internal Medicine, Goa Medical College and Hospital, Bambolim, IND.
Introduction: Stroke is the leading cause of disability and death worldwide, often resulting from disrupted blood flow to the brain. Smoking is a well-established risk factor that significantly increases the likelihood of stroke by damaging blood vessels and promoting clot formation. Aim and objective: This study aimed to assess the association between smoking status and self-reported stroke, considering demographic and socioeconomic factors.
View Article and Find Full Text PDF