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http://dx.doi.org/10.1155/2018/4956491 | DOI Listing |
Bioact Mater
December 2025
School of Materials Science and Engineering, Peking University, Beijing, 100871, China.
The intricate degradation dynamics exhibited by biodegradable alloys significantly influence host responses during the implantation process, posing challenges in achieving stable osseointegration. It is thus critical to tailor the biodegradation profiles of these implants to establish a conductive tissue microenvironment for bone tissue regeneration. In this study, we demonstrate that Zn-Li alloy forms a layer of Li-containing degradation products at the bone-implant interface to accommodate the bone regeneration process.
View Article and Find Full Text PDFMater Today Bio
October 2025
Department of Oral Special Consultation, The Affiliated Stomatological Hospital of Nanjing Medical University, Nanjing, People's Republic of China.
Periprosthetic osteolysis remains a major cause of implant failure, driven by inflammatory responses to titanium (Ti) wear particles and ions. Inflammatory bowel disease (IBD), a systemic chronic inflammatory condition, exacerbates bone loss, yet its synergistic effects with Ti ions on periprosthetic osteolysis remain unexplored. Here, we investigated how IBD and Ti ions impair bone-implant integration by disrupting osteogenesis via the PI3K/AKT pathway.
View Article and Find Full Text PDFBMC Biotechnol
September 2025
Department of Orthopedics, The Second Affiliated Hospital of Xi'an Jiagtong University, Xi'an, China.
Unlabelled: Ti6Al4V (TC4) widely used in bone implants, has good mechanical properties but unremarkable bone-forming capacity. Tantalum (Ta) features excellent biocompatibility and suitability for osteogenesis, albeit with a significantly higher elastic-modulus. In this study, we combined the strengths of both materials to optimize implant materials.
View Article and Find Full Text PDFAdv Sci (Weinh)
August 2025
Institute of Translational Medicine, Shanghai University, Shanghai, 200444, P. R. China.
As global population aging intensifies, bone-related diseases have become a significant public health challenge, necessitating the development of efficient and precise bone repair strategies. Biocompatible mesoporous materials (BMMs), characterized by their high specific surface area, tunable pore size, multidimensional functionalization potential, and excellent biocompatibility, have demonstrated revolutionary application prospects in treating bone-related diseases. This review systematically summarizes the latest research progress and application mechanisms of BMMs (e.
View Article and Find Full Text PDFJ Mech Behav Biomed Mater
August 2025
ARTORG Center for Biomedical Engineering Research, University of Bern, Switzerland.
Primary stability of pedicle screws is critical for successful spinal fixation, particularly in osteoporotic patients, where screw loosening occurs in over 50 % of cases. This study combined experimental and numerical approaches to evaluate the primary stability of carbon fibre-reinforced polyether-ether-ketone (CF/PEEK) screws under toggling loading conditions. Fifteen human cadaveric vertebrae with low bone mineral density were tested using a multidirectional loading setup with custom-designed, 3D-printed guides for accurate screw placement.
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