Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Objective: This case series evaluates the safety and effectiveness of 3D-printed scaffold in chronic wounds. The scaffold is a composite of natural and synthetic materials, and can be prepared in the form of powder or membrane.
Method: We recruited patients with pressure ulcera (PU) and/or a diabetic foot ulcers (DFU). We used two methods: 3D-printed scaffolds alone, or 3D-printing powder mixed with platelet-rich fibrinogen (PRF). Clinicians and patients were asked to rate the scaffold's ease of application and comfort during use.
Results: A total of five patients were recruited; four with a PU and one with a DFU. For the patient treated with the 3D-printed scaffold membrane (n=1), their PU healed in 28 days, and for patients treated with the 3D-printed scaffold powder (n=2), their PUs healed in 54 days. For the patients treated with the 3D-printing powder mixed with PRF (n=2), the patient with a PU healed in 11 days, and the patient with the DFU healed in 14 days. All clinicians rated the 3D-printed scaffold as 'easy' or 'very easy' to use, and patients rated their comfort during wear and at dressing change as 'good' or 'very good'.
Conclusion: This study demonstrated that 3D-printed scaffold was convenient to use, have the potential to improve wound healing rates, and provided a safe and effective way for treating chronic wounds.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.12968/jowc.2018.27.5.262 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
α-Cyclodextrin mediated 3D printed ceramic/polymer composite scaffolds for immunomodulation and osteogenesis in bone defect repair.
Biomater Adv
September 2025
Quanzhou Institute of Equipment Manufacturing, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou, Fujian, 350002, China; Fujian Science and Technology Innovation Laboratory for Optoelectronic Information of China, Fuzhou, Fujian, 350108, China; University o
Bone tissue engineering scaffolds for bone defect treatment face numerous challenges, including mechanical mismatches and the lack of immune microenvironment modulation, often leading to implant failure. In this study, an innovative drug-loaded bioinspired ceramic/polymer composite scaffold was designed and fabricated using extrusion-based 3D printing technology, incorporating α-cyclodextrin (αCD) in a novel approach to improve interfacial compatibility and drug-loading efficiency. Hydroxyapatite (HA), the main component of natural bone, was employed as the inorganic phase to mimic the mineral structure of bone tissue.
View Article and Find Full Text PDFSurface modification of polycaprolactone with sulfated alginate for enhanced binding of a heparin-binding protein.
J Mater Chem B
September 2025
School of Chemistry and Molecular Biosciences, The University of Queensland, St Lucia 4072, Australia.
Surface modification of poly(ε-caprolactone) (PCL) to facilitate interactions with high pI proteins is a strategy used to enhance 3D PCL scaffolds for tissue engineering applications. The approach of the current study was to firstly optimise the surface modification on 2D films and then apply to 3D scaffolds. Melt-pressed PCL films were grafted with 2-aminoethyl methacrylate gamma radiation induced grafting to introduce amine functional groups to the substrate surfaces.
View Article and Find Full Text PDFCritical-sized bone defects present significant clinical challenges due to inadequate vascularization and scaffold integration. This study developed a multifunctional 3D-printed polycaprolactone (PCL)-gelatin (Gel) scaffold reinforced with Bioglass particles (BGPs) or copper dopped BGPs (CuBGPs) to synergistically enhance angiogenesis and bone regeneration in rat model. The scaffolds were fabricated by infiltrating gelatin solutions containing BGPs or CuBGPs into the pores of 3D-printed PCL matrices, followed by freeze-drying.
View Article and Find Full Text PDFOptogenetic neuromuscular actuation of a miniature electronic biohybrid robot.
Sci Robot
September 2025
Nick J. Holonyak Micro and Nanotechnology Laboratory, Grainger College of Engineering, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.
Neuronal control of skeletal muscle function is ubiquitous across species for locomotion and doing work. In particular, emergent behaviors of neurons in biohybrid neuromuscular systems can advance bioinspired locomotion research. Although recent studies have demonstrated that chemical or optogenetic stimulation of neurons can control muscular actuation through the neuromuscular junction (NMJ), the correlation between neuronal activities and resulting modulation in the muscle responses is less understood, hindering the engineering of high-level functional biohybrid systems.
View Article and Find Full Text PDF3D printed antibacterial and anti-inflammatory scaffold containing vanillin-loaded Soluplus nanomicelles for healing of infected wounds.
Sci Rep
September 2025
Department of Materials Engineering, Isfahan University of Technology, Isfahan, 84156-83111, Iran.
Treating infected wounds is a major clinical challenge, and concerns about bacterial resistance have driven the shift toward natural antimicrobials over antibiotics. Herein, a 3D printed scaffold wound dressing consisting of alginate (Alg) and fucoidan (F) was prepared, and Soluplus (Sol) nanomicelles (NMs) were used to load vanillin (Vn) as a lipophilic antibacterial agent into the 3D printed scaffold. Characterization analyses revealed that the fabricated scaffold exhibited a peak swelling capacity of 294.
View Article and Find Full Text PDF