Article Synopsis
- A new optical coherence tomography (OCT) system features a 19 MHz laser and electronically synchronized components for improved imaging.
- The system uses advanced technology, such as an electro-optic modulator and MEMS mirrors, to achieve fast beam scanning and high-speed data acquisition at 1.78 Gigasamples per second.
- It enables detailed imaging techniques like inter-frame and inter-volume Doppler imaging in mouse models, providing valuable insights into blood flow and tissue perfusion dynamics for preclinical research.
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Article Abstract
We present a swept-wavelength optical coherence tomography (OCT) system with a 19 MHz laser source and electronic phase-locking of the source, acquisition clock, and beam scanning mirrors. The laser is based on stretched-pulse active mode-locking using an electro-optic modulator. Beam scanning in the fast axis uses a resonant micro-electromechanical systems (MEMS) -based mirror at ~23.8 kHz. Acquisition is performed at 1.78 Gigasamples per second using an external fixed clock. Phase sensitive imaging without need for k-clocking, A-line triggers, or phase-calibration methods is demonstrated. The system was used to demonstrate inter-frame and inter-volume Doppler imaging in the mouse ear and brain at 4D acquisition rates of 1, 30, 60 and 100 volumes/sec (V-scans/s). Angiography based on inter-frame and inter-volume methods are presented. The platform offers extremely fast and phase-stable measurements that can be used in preclinical angiographic and Doppler investigations of perfusion dynamics.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5846541 | PMC |
| http://dx.doi.org/10.1364/BOE.9.000952 | DOI Listing |
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