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Article Abstract
Background: Disease specific autoantibodies have been detected in the sera of patients with atherosclerosis-related diseases, such as cerebral infarction, cardiovascular disease. In the present study, we aimed to identify novel autoantibodies responsible for transient ischemic attack (TIA), a prodromal condition for cerebral infarction.
Methods: To identify candidate antigens, we screened a human aortic endothelial cell cDNA library using sera from 20 patients with TIA. Serum antibody levels were measured using amplified luminescent proximity homogeneous assay-linked immunosorbent assay (AlphaLISA) in 2 independent patient/healthy donor (HD) cohorts ( = 192 and = 906 in the second screening and validation cohort, respectively).
Results: First screening identified 3 candidate antigens. Of these, programmed cell death 11 (PDCD11) was determined to be associated with stroke ( < 0.0001), as evidenced from the second screening using AlphaLISA. The validation cohort revealed significantly higher antibody levels against PDCD11 (PDCD11-Ab levels) in patients with TIA than in HDs. Multivariate logistic regression analysis indicated that the predictive value of PDCD11-Ab levels for TIA [Odds ratio (OR): 2.44, 95% confidence interval (CI): 1.33-4.57, = 0.0039] was not inferior to other known risk factors for ischemic stroke, including age (OR: 4.97, 95% CI: 2.67-9.48, < 0.0001); hypertension (OR: 3.21, 95% CI: 1.76-5.86, = 0.0001); and diabetes (OR: 4.31, 95% CI: 1.74-11.2, = 0.0015).
Conclusion: Serum PDCD11-Ab level may serve as a potential biomarker for TIA.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5823671 | PMC |
| http://dx.doi.org/10.18632/oncotarget.23653 | DOI Listing |
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