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Article Abstract
The duplication of 5' segment of is a rare molecular event in childhood leukemia, and the influence on prognosis is unknown. Here, we report on a boy who developed acute monocytic leukemia. Fluorescence in situ hybridization revealed the duplication of the 5' segment with 2 normal alleles at which was eventually found to be fused with . Chemotherapy promptly induced the first complete remission in the patient at our facility, and the patient remained in first complete remission with negative minimal residual disease at 3.5 years from diagnosis. Our case is similar to two previously reported patients who had partial duplication of the 5' segment of with a - rearrangement. Further studies and experience with this cryptic translocation may shed more light on the management of acute myeloid leukemia.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5763053 | PMC |
| http://dx.doi.org/10.1155/2017/6257494 | DOI Listing |
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