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http://dx.doi.org/10.1164/rccm.201801-0048LE | DOI Listing |
Br J Pharmacol
September 2025
Department of Physiology and Medical Physics, RCSI University of Medicine and Health Sciences, Dublin, Ireland.
Background And Purpose: Neuroinflammation is increasingly recognised to contribute to drug-resistant epilepsy. Activation of ATP-gated P2X7 receptors has emerged as an important upstream mechanism, and increased P2X7 receptor expression is present in the seizure focus in rodent models and patients. Pharmacological antagonists of P2X7 receptors attenuate seizures in rodents, but this has not been explored in human neural networks.
View Article and Find Full Text PDFClin Oral Investig
September 2025
Department of Stomatology, Shengli Oilfield Central Hospital, No. 31, Jinan Road, Dongying, 257034, China.
Objective: Progesterone (PG) and its target, progesterone receptor (PGR), are important regulators in inflammatory diseases. This study aimed to investigate the specific role of PG in periodontitis and to elucidate the underlying mechanisms involving PGR.
Methods: Women with periodontitis, including 250 with PG deficiency, 250 with PG supplementation, and 245 controls (normal PG) were enrolled.
Intern Med
September 2025
Respiratory Medicine and Infectious Diseases, Oita University Faculty of Medicine, Japan.
Objective Although nintedanib is commonly used to treat interstitial lung disease (ILD), its clinical utility is often limited by adverse gastrointestinal events. Ramosetron, a selective 5-HT receptor antagonist, has shown efficacy in managing irritable bowel syndrome; however, its effects on nintedanib-associated abdominal symptoms remain unclear. This study evaluated the effect of ramosetron on continuation of nintedanib therapy.
View Article and Find Full Text PDFInt J Cardiol
December 2025
Department of Otorhinolaryngology Head and Neck Surgery, the Affiliated People's Hospital of Ningbo University, Ningbo, Zhejiang, China. Electronic address:
BMJ Open
September 2025
Department of Interventional Radiology, The First Hospital of China Medical University, Shenyang, Liaoning, China
Background: Advanced-stage hepatocellular carcinoma (HCC) with high tumour burden and portal vein tumour thrombus (PVTT) is usually associated with poor survival outcomes. Rapid tumour control usually benefits long-term outcomes, which could be hardly achieved by solely systematic targeted and immunotherapy in current guidelines. Hepatic arterial infusion chemotherapy (HAIC) is reported as an effective intervention for rapid decrease of tumour burden.
View Article and Find Full Text PDF