Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Background: The aim of this study was to investigate the impact of diosgenin, an important monomer of sapogenins in yams, on ovarian reserve in a natural aging mice model.
Study Design: This randomized controlled trial included 60 9-month-old C57 naturally aging female mice. Twenty-one mice were assigned to the dio group and were fed a single dose of diosgenin (200 mg/kg/day) suspended in 0.3% CMC. Twenty mice were assigned to the DHEA group and were fed a single dose of DHEA (1.25 mg/kg/day) suspended in 0.3% CMC. The remaining 20 mice were assigned to the old control group and were fed a single dose of 0.3% CMC. Three months later, the reproductive performance of these female mice was determined by evaluating ovarian follicles and oocyte number and quality in IVF and comparing age-matched and young controls. The impact of NOBOX, GDF9 and BMP15 mRNA expression was also evaluated.
Results: Diosgenin improves ovarian reserve in naturally aging mice in terms of increasing the number of primary follicles (P < 0.05) and serum levels of AMH (P < 0.05).
Conclusions: Diosgenin could counteract age-associated ovarian dysfunction by improving the ovarian reserve in a natural aging mice model.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5648463 | PMC |
| http://dx.doi.org/10.1186/s40001-017-0285-6 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Pregnancy and breast cancer in young women: current updates and future directions.
Ther Adv Med Oncol
September 2025
Division of Surgical Oncology, Department of Surgery, University of California, Los Angeles, 15503 Ventura Blvd, Suite 150, Los Angeles, CA 90095, USA.
The relationship between pregnancy and breast cancer is complicated. On one hand, pregnancy can influence breast cancer risk and tumor biology, and on the other, a breast cancer diagnosis and its subsequent management can significantly affect fertility, family planning, and future pregnancies. This interaction presents challenges unique to young women with breast cancer (YWBC).
View Article and Find Full Text PDFResearch Progress on Ferroptosis Regulation of Female Reproduction.
Biol Trace Elem Res
September 2025
State Key Laboratory of Swine and Poultry Breeding Industry, College of Animal Science and Technology, Sichuan Agricultural University, Chengdu, 611130, China.
Ferroptosis is a form of iron-regulated cell death that plays a critical role in various aspects of female reproductive system development. These processes include the normal estrous cycle, ovarian formation, follicular maturation, ovulation, and pregnancy, all of which are essential for maintaining reproductive health in female animals. However, excessive iron leads to the accumulation of reactive oxygen species within cells, disrupting intracellular redox balance, inducing mitophagy, membrane rupture, and lipid peroxidation, which can damage tissues and cells, ultimately resulting in ferroptosis.
View Article and Find Full Text PDFImpact of gonadotropin genetic profile and ovarian reserve on controlled ovarian stimulation: data from prospective cohort of the GENOCS trial.
Front Endocrinol (Lausanne)
September 2025
Gynecology/Obstetrics Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Introduction: Several studies indicate that a specific genotype profile could influence ovarian sensitivity to exogenous gonadotropin. However, most of the previous studies were observational and retrospective and thereby more prone to bias. The aim of this study was to evaluate the impact of gonadotropin single nucleotide polymorphisms (SNPs) on the outcomes of fertilization (IVF) in infertile patients undergoing their first ovarian stimulation (OS) cycle.
View Article and Find Full Text PDFGADD45A is Essential for Granulosa Cells Differentiation and Ovarian Reserve in Human and Mice.
J Cell Mol Med
September 2025
Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, Chengdu, China.
Diminished ovarian reserve (DOR) poses significant challenges in reproductive health, with emerging evidence implicating DNA damage repair pathways. While GADD45A is a critical regulator of DNA repair, cell cycle and apoptosis, its role in DOR pathogenesis remains unexplored. We employed transcriptome sequencing, qPCR and Western Blot analyses to compare GADD45A expression in granulosa cells (GCs) between DOR patients and controls.
View Article and Find Full Text PDFOvarian reserve markers in women of reproductive ages with epilepsy.
Epilepsy Behav
September 2025
The Epilepsy Clinic, Department of Neurology, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark.
Objective: The objective of this study was to examine ovarian reserve parameters in women with epilepsy compared to women without epilepsy.
Methods: A total of 80 women with epilepsy (WWE) from the epilepsy clinic at Rigshospitalet, Denmark, participated and completed the study between 2018-2022. A historical cohort collected from 2008 to 2010 of 418 women without epilepsy and no prior diagnosis of infertility was used as control.