Asymmetric synthesis of CF-containing tetrahydroquinoline via a thiourea-catalyzed cascade reaction.

Org Biomol Chem

The Institute of Pharmacology, Key Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Basic Medical Sciences, Lanzhou University, Lanzhou 730000, China.

Published: May 2017


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Article Abstract

An organocatalytic asymmetric method for the synthesis of 2-CF tetrahydroquinoline has been achieved. The cascade reaction of 2-aminochalcones with β-CF nitroalkenes afforded the products bearing three contiguous stereogenic centers in good yields with excellent diastereoselectivities and enantioselectivities.

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http://dx.doi.org/10.1039/c7ob01013cDOI Listing

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