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Craving, as a central feature of addiction and a precursor of relapse, is targeted recently in addiction intervention. While Internet gaming disorder (IGD), conceptualized as a behavioral addiction, is lack of effective treatment practice and exploration of its mechanism. This research aims to test the effectiveness and detect the active ingredients of craving behavior intervention (CBI) in mitigation of IGD among young adults. A total of 63 male college students with IGD were assigned into the intervention group (six-session CBI intervention) or the waiting-list control group. Structured questionnaires were administered at pre-intervention (T1), post-intervention (T2), 3-month follow-up (T3), and 6-month follow-up (T4). Compared to the control group, a significant decrease in the severity of IGD in intervention group was found at post-intervention and lasting to 6 months after intervention. The value changes of craving could partially mediate the relationship between intervention and changes of IGD among all effects tests (immediate, T2-T1; short-term, T3-T1; and long-term effects, T4-T1). Further, explorations of the active ingredients of intervention found depression relief and shift of psychological needs from Internet to real life significantly predict craving amelioration at both post-intervention and 6-month follow-up. Although preliminary, the current study provides evidence for the value of craving-aimed intervention practice in IGD treatment and identifies two potential active ingredients for mitigation of craving, and the long-term therapeutic benefits are further conferred. Registry name: The behavioral and brain mechanism of IGD; URL: https://www.clinicaltrials.gov/ct2/show/NCT02550405; Registration number: NCT02550405.
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http://dx.doi.org/10.3389/fpsyg.2017.00526 | DOI Listing |
Biomed Chromatogr
October 2025
Department of Rehabilitation, Nan'ao People's Hospital, Shenzhen, China.
Chrysotobibenzyl, a bioactive ingredient from Dendrobium chrysotoxum, exhibits potent anti-tumor activity. However, its metabolic profiles remain unelucidated. This study aimed to disclose the metabolic fates of chrysotobibenzyl using human liver fractions.
View Article and Find Full Text PDFChem Pharm Bull (Tokyo)
September 2025
National Institute of Health Sciences, 3-25-26 Tonomachi, Kawasaki-ku, Kawasaki 210-9501, Japan.
The development of analytical techniques applicable to powdered pharmaceutical co-crystals, including those containing excipients, represents a comprehensive strategy for quality control in both drug development and regulatory settings. This study investigates the structural characterization of indomethacin-nicotinamide co-crystals using a combination of microcrystal electron diffraction (microED), solid-state NMR (SSNMR), Raman spectroscopy, and powder X-ray diffraction (PXRD). MicroED analysis revealed the crystal structure of the co-crystal, while SSNMR measurements provided insights into the molecular interactions within the structure.
View Article and Find Full Text PDFJ Adv Res
September 2025
State Key Laboratory for Quality and Safety of Agro-Products, Key Laboratory for Pesticide Residue Detection of Ministry of Agriculture and Rural Affairs, Institute of Agro-Product Safety and Nutrition, Zhejiang Academy of Agricultural Sciences, Hangzhou 310021, China. Electronic address: tangtao@za
Introduction: Microencapsulated pyraclostrobin (PYR-CS) has gained widespread adoption in agriculture owing to its extended efficacy and reduced risks for non-target organisms. However, knowledge remains limited regarding its degradation in soil and effects on soil microorganisms.
Objectives: This study investigates the hypothesis that microencapsulation alters pyraclostrobin degradation and reshapes soil microbial communities compared with conventional formulations, including emulsifiable concentrate (PYR-EC) and technical material (PYR-TC).
Bioresour Technol
September 2025
School of Chemical Engineering, Xiangtan University, Xiangtan 411105, China. Electronic address:
Biomass containing inorganic ingredients can be converted into highly porous biochar via in-situ activation and templating process. Here, N-doped biochar is obtained by pyrolysis of spinach organs for efficient dye removal, using methylene blue (MB) as a model dye, and pyrolysis temperature plays a critical role in determining both porosity and N-species within biochar. Significantly, leaf biochar (LC-900) as pyrolyzed at 900 °C shows surface areas of 1263 m/g larger than that of biochar from stem and root, indicating a dependence on the biomass organ source.
View Article and Find Full Text PDFNanoscale Horiz
September 2025
CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Chinese Academy of Sciences and National Center for Nanoscience and Technology of China, Beijing 100190, China.
Central nervous system (CNS) diseases, including neurodegenerative diseases, stroke, brain tumors, and others, result in poor quality of life and can cause substantial disability. Not all CNS diseases are amenable to surgical approaches, so drug development is important for disease treatment. Unfortunately, there are few drugs currently available for CNS diseases.
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