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Purpose: This study aimed to evaluate the statistical noise of motion-frozen (MF) image generated by gated myocardial perfusion single photon emission computed tomography (SPECT) imaging using IQ · SPECT and to determine the optimal acquisition and reconstruction parameters for MF image using IQ · SPECT.
Methods: A movement cardiac phantom and static cardiac phantom were used to acquire the MF images. The acquisition times used were different in 8 and 16 frames per R-R interval, and varying reconstruction parameters (subset and iteration) were used. We determined the %CV value, contrast, and normalized mean square error (NMSE) to evaluate the image quality.
Results: The %CV value for a MF image with IQ · SPECT was lower than that for a conventional non-gated myocardial perfusion SPECT (MPS) image with low energy high resolution (LEHR). With regard to the acquisition parameters, the contrast did not change when the acquisition time was increased in 8 and 16 frames per R-R interval. NMSE converged in 56 beats/view in 8 frames per R-R interval. With regard to the reconstruction parameters, the contrast and the %CV value of the anterior and septal wall converged in update 40. The minimum NMSE in subsets 1, 2, and 3 were almost similar.
Conclusions: Uniformity in the MF image with IQ · SPECT was higher than that in the conventional image. The results of this MF image with IQ · SPECT study suggest that the optimal acquisition parameter should be 56 beats/view in 8 frames per R-R interval, and the optimal reconstruction parameters should be subset 3 and iteration 14.
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http://dx.doi.org/10.6009/jjrt.2017_JSRT_73.4.282 | DOI Listing |
CNS Neurosci Ther
September 2025
Department of Functional Neurosurgery, Beijing Institute of Functional Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, China.
Aim: A total of 30% of individuals with epilepsy are resistant to drug treatment. Deep brain stimulation (DBS) of the anterior nucleus of the thalamus (ANT) shows promise for treating drug-resistant epilepsy (DRE), but further research is needed to optimize DBS parameters, including stimulation frequency. This study aimed to reveal the optimal frequency for ANT-DBS by testing the real-time effects of various stimulation frequencies on the ANT among patients undergoing stereoelectroencephalography (SEEG) electrode implantation.
View Article and Find Full Text PDFBMJ Open
September 2025
Department of Rehabilitation, Shengjing Hospital of China Medical University, Shenyang, Liaoning, Chinax
Objectives: This study evaluated the effects of proximal core training on biomechanical risk factors and strength parameters in individuals at high risk of anterior cruciate ligament (ACL) injury (specifically: those exhibiting pathological movement patterns, neuromuscular deficits or biomechanical risk factors) and compared direct versus indirect interventions. We hypothesised that targeted training enhances dynamic knee stabilisation and hip control during high-risk manoeuvres, with direct approaches providing superior biomechanical benefits through neuromuscular control optimisation.
Design: Systematic review and meta-analysis using the Grading of Recommendation, Assessment, Development and Evaluation (GRADE) approach.
JMIR Med Inform
September 2025
Department of Mechanical and Industrial Engineering, Faculty of Engineering, University of Toronto, Toronto, ON, Canada.
Background: Total knee and hip arthroplasty (TKA and THA) are among the most performed elective procedures. Rising demand and the resource-intensive nature of these procedures have contributed to longer wait times despite significant health care investment. Current scheduling methods often rely on average surgical durations, overlooking patient-specific variability.
View Article and Find Full Text PDFJ Med Internet Res
September 2025
Department of Internal Medicine, Seoul National University College of Medicine, 101 Daehak-ro, Jongno-gu, Seoul, 03080, Republic of Korea, 82 0220721965.
Background: Biological age (BA) is increasingly recognized as a valuable alternative to chronological age (CA) for assessing an individual's health and aging status. However, existing models are based on limited clinical parameters and have not thoroughly integrated morbidity and mortality data.
Objective: This study aimed to develop and validate a novel transformer-based model, referred to as the BA - CA gap model, for BA estimation that incorporates morbidity and mortality information to improve predictive accuracy and enhance clinical use in the early identification of the risk of age-related diseases.
Comput Methods Programs Biomed
September 2025
Department of Medical Imaging and Radiation Sciences, School of Primary and Allied Health Care, Faculty of Medicine, Nursing and Health Sciences, Monash University, Australia. Electronic address:
Background And Purpose: Several studies have shown changes in neurochemicals within the deep-brain nuclei of patients with psychosis. These alterations indicate a dysfunction in dopamine within subcortical regions affected by fluctuations in iron concentrations. Quantitative Susceptibility Mapping (QSM) is a method employed to measure iron concentration, offering a potential means to identify dopamine dysfunction in these subcortical areas.
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