Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
A double-layered model is proposed for numerically simulating osteoblast adhesion on surface-engineered biomaterials. The proposed model consists of molecular and cellular motions based on theoretical and experimental evidence and creates predictive simulations from sparse experimental data. The comparison of numerical solutions and experimental data reveals that the proposed model can explain the nonlinear behaviour of osteoblast adhesion on material surfaces in respect to nanophase grain size (0-100 nm). The model further provides insight into the optimisation of nanophase grain size on the surface of the biomaterial.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1080/10255842.2017.1314468 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Electroactive ceramic biomaterials on the principle of bone piezoelectricity towards advanced bone engineering.
Biomater Adv
September 2025
Graduate School of Medical and Dental Science, Institute of Science Tokyo, 15-45 Yushima, Bunkyo, Tokyo, 113-8510, Japan; Advanced Central Research Organization, Teikyo University, 2-11-1, Kaga, Itabashi, Tokyo, 173-8605, Japan.
This review concentrates on the electroactive ceramic biointerfaces inspired by bone piezoelectricity for advanced ceramic biomaterials. Bone generates electrical potentials through the piezoelectric properties of collagen fibrils and apatite minerals under mechanical loading. These electrical signals influence osteoconductivity and regenerative capacity by osteogenic cells.
View Article and Find Full Text PDFHyaluronic acid promotes biomineralization of osteoblast-like cells - observations on two different barrier membranes.
Int J Implant Dent
September 2025
Department of Periodontology, Center for Biomedical Education and Research (ZBAF), School of Dentistry, Faculty of Health, Witten/Herdecke University, Witten, Germany.
Background: Guided bone regeneration (GBR) relies on biocompatible membranes to support osteogenesis. 1,4-butanediol diglycidyl ether (BDDE)-crosslinked hyaluronic acid (xHyA) has shown promise in enhancing bone regeneration, yet its mechanisms remain unclear.
Objective: This study evaluates the osteogenic effects of xHyA-functionalized native pericardium collagen membrane (NPCM) and ribose-crosslinked collagen membrane (RCCM) using an airlift culture model with SaOS-2 cells.
Levo-Tryptophan Promotes Osteogenesis Through Calcium-Sensing Receptor.
FASEB Bioadv
August 2025
Laboratory of Molecular Signaling and Stem Cells Therapy, Beijing Key Laboratory of Tooth Regeneration and Function Reconstruction Beijing Stomatological Hospital, School of Stomatology, Capital Medical University Beijing China.
Previous studies reported the pro-osteogenic ability of L-Tryptophan (L-Trp) and Calcium-Sensing RCeceptor (CaSR) respectively. Recent researchers found L-Trp could activate CaSR. Therefore, this study investigated the osteogenic mechanisms of L-Trp through CaSR activation.
View Article and Find Full Text PDFAn antibacterial dual-network polyelectrolyte coating for orthopedic implant.
Colloids Surf B Biointerfaces
August 2025
Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310058, China. Electronic address:
Bacterial infections, aseptic loosening, and poor osseointegration remain challenges for orthopedic implants. In this study, we developed a dual-network polyelectrolyte antibacterial coating for orthopedic implants to prevent bacterial infections. The coating was prepared via UV-triggered in situ polymerization, composed of polyethyleneimine (PEI) and polyacrylic acid (PAA), with enhanced mechanical properties due to electrostatic interactions between them.
View Article and Find Full Text PDFRole and mechanism of Integrin α5β1 in bone formation and disease.
Front Cell Dev Biol
August 2025
School of Sports Health, Shenyang Sport University, Shenyang, China.
Integrin α5β1 is a key signaling protein between cells and the extracellular matrix. It plays crucial roles in biological processes such as cell adhesion, migration, and differentiation. Recent studies have shown that integrin α5β1 is significantly involved in bone formation and related diseases.
View Article and Find Full Text PDF