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The progress of magnetic resonance imaging (MRI) allows for a precise exploration of the brain of premature infants at term equivalent age. The so-called DEHSI (diffuse excessive high signal intensity) of the white matter of premature brains remains a challenging issue in terms of definition, and thus of interpretation. We propose a semi-automatic detection and quantification method of white matter hyperintensities in MRI relying on morphological operators and max-tree representations, which constitutes a powerful tool to help radiologists to improve their interpretation. Results show better reproducibility and robustness than interactive segmentation.
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http://dx.doi.org/10.1109/EMBC.2016.7590648 | DOI Listing |
Brain Res Bull
September 2025
Department of Neurology, The Second Affiliated Hospital of Anhui Medical University, 230601, He Fei, China; Collaborative Innovation Center of Neuropsychiatric Disorders and Mental Health, 230032, Hefei, China; Anhui Province Key Laboratory of Cognition and Neuropsychiatric Disorders, 230032, Hefei,
Background: The relationships between white matter microstructure, cortical atrophy, and cognitive function in cerebral small vessel disease (CSVD)-related white matter hyperintensities (WMHs) patients are unclear.
Methods: 71 right-handed WMHs patients (mild, n=23; moderate, n=27; severe, n=21) and 35 healthy controls were included. Tract-based spatial statistics (TBSS) assessed microstructure via fractional anisotropy (FA) and mean diffusivity (MD).
Exp Neurol
September 2025
CNRS UMR 5536 RMSB, University of Bordeaux, Bordeaux, France; Basic Science Department, Loma Linda University School of Medicine, Loma Linda, CA, USA; CNRS UMR 7372 CEBC, La Rochelle University, Villiers-en-Bois, France.
Introduction: The vulnerability of white matter (WM) in acute and chronic moderate-severe traumatic brain injury (TBI) has been established. In concussion syndromes, including preclinical rodent models, lacking are comprehensive longitudinal studies spanning the mouse lifespan. We previously reported early WM modifications using clinically relevant neuroimaging and histological measures in a model of juvenile concussion at one month post injury (mpi) who then exhibited cognitive deficits at 12mpi.
View Article and Find Full Text PDFBehav Brain Res
September 2025
Key Laboratory of Endocrine Glucose & Lipids Metabolism and Brain Aging, Ministry of Education, Department of Radiology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jing-wu Road No. 324, Jinan 250021, Shandong, China. Electronic address:
Postpartum Depression (PPD) is a significant perinatal mood disorder affecting many new mothers in the first postpartum year. It is characterized by emotional, cognitive, and behavioral changes, often leading to delayed diagnosis due to nonspecific symptoms. PPD arises from a complex interplay of neuroendocrine, genetic, and psychosocial factors.
View Article and Find Full Text PDFJ Proteome Res
September 2025
Department of Pediatrics, Jagiellonian University Medical College, Wielicka 265 Street, 30-663 Krakow, Poland.
Premature infants are at high risk for brain injuries such as intraventricular hemorrhage and periventricular white matter injury. This study applies omics technology to analyze urinary protein expression, aiming to clarify preterm brain injury mechanisms and identify therapeutic targets. Urine samples were collected from 29 very preterm infants (VPI) without brain injury and 11 with moderate/severe injury at eight time points: Days 1, 2, 3, 4, 6, 8, 28, and term-equivalent age (TEA).
View Article and Find Full Text PDFCuad Bioet
September 2025
Facultad de Farmacia y Nutrición de la Universidad de Navarra, Irunlarrea, 1, 31008 Pamplona.
In recent years, there has been a significant increase in minors with gender dysphoria (GD) seeking transition treatments, including puberty blockers and cross-sex hormones. The developing child's brain exhibits structural and functional differences in children with GD compared to cisgender children, particularly in areas where sex differences exist. Brain development during childhood and adolescence is strongly influenced by sex hormones.
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